| TLR4在病理性心脏重构中的作用 |
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| 引用本文： | 彭建业,黄鹤. TLR4在病理性心脏重构中的作用[J]. 心脏杂志, 2017, 29(4): 487-490. DOI: 10.13191/j.chj.2017.0122 |
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| 作者姓名： | 彭建业 黄鹤 |
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| 作者单位： | 1. 武汉大学人民医院心内科, 湖北 武汉 430060; |
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| 基金项目： | 湖北省科技支撑计划项目资助（2013BCB013）； 国家自然科学基金项目资助（81270249，81570306） |
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| 摘 要： | Toll样受体（Toll like receptors，TLRs）是一类跨膜受体家族，在先天性免疫反应和获得性免疫反应中都发挥关键作用。TLR4是最早被发现的 TLR，能识别脂多糖和器官损伤后释放的内源性配体。越来越多的研究证实，TLR4及其介导的信号通路与病理性心脏重构密切相关。本文系统综述了TLR4在压力超负荷或高血压所致心脏重构、缺血/再灌注（I/R）或心肌梗死（MI）后心脏重构和糖尿病心脏重构中的作用及相关机制的研究进展。
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| 关 键 词： | Toll样受体4 信号通路 病理性心脏重构 |
| 收稿时间： | 2016-08-29 |
Role of Toll like receptor 4 in pathological cardiac remodeling |
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| Affiliation: | 1. Department of Cardiology, Renmin Hospital, Wuhan 430060, Hubei, China;2. Cardiovascular Research Institute, Wuhan University, Wuhan 430060, Hubei, China;3. Hubei Key Laboratory of Cardiology, Wuhan 430060, Hubei, China |
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| Abstract: | Toll-like receptors (TLRs) are a family of transmembrane receptors that play a key role in both innate and acquired immunity responses. The TLR first discovered is TLR4 and it recognizes lipopolysaccharides and endogenous ligands released after organ injury. A growing body of studies suggest that TLR4 and TLR4-mediated signaling pathways are closely related to pathological cardiac remodeling. This article systematically reviews current studies on the role and related mechanisms of TLR4 in pathological cardiac remodeling, which is caused by pressure overload or high blood pressure, by ischemia/reperfusion (I/R) or myocardial infarction (MI) and by diabetes. |
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