注射用抑肽酶在胸外科围手术期中的应用

目的探讨抑肽酶对胸外科围手术期的凝血-纤溶系统的影响。方法54例食管癌和46例肺癌手术患者,随机分为治疗组对照组:检查不同时间血液凝固启动时间(CST)、最大凝固程度(MCE)、纤维蛋白完全溶解时间(WFT)的改变。结果 治疗组CST在术后2小时、24小时明显减少,与对照组比较有极显著差异(P<0.01)。而术前及术后48小时以上两组没有显著差别;MCE、WFT在术前30分钟及术后2小时、24小时均明显高于对照组(P<0.01).而术后48小时后与对照组比较无显著差异。结论胸外科围手术期使用抑肽酶能有效的调节凝血-纤溶系统,对防止术中及术后出血有显著的疗效。

Aprotinin's effect on blood coagulation and fibrinolysis system during perioperation of thorax period

Objective To study aprotinin' s effect on blood coagulation and fibrinolysis system.Methods 54 esophagectomy' s and 46 pulmonectomy' s cases were randomly divided into aprotinin group (A) and control group(B) ,the results of CST,MCE,WFT were detected in different time (30 minute before operation and 2h,24h,48h, 72h of postoperation) .Results Compared with Group B,it is obvious to reduce in CST in 2h,24h of postoperation(P<0.01) ,and there were no significant difference before operation and 48h,72h of postoperation,Meanwhile,MCE and WFT was markedly increased in 30 minute before operation and 2h,24h of postoperation (P<0.01) .there were no significant difference after postoperation 48h.Conclusions Aprotinin ate blood coagulation and fibrinolysis system during esophagectomy' s and pulmonectomy' s period,and markedly ameliorate the blood loss.