急性心肌梗死患者N末端B型钠尿肽水平与梗死后短期心力衰竭的关系

目的探讨急性心肌梗死(AMI)患者N末端B型钠尿肽(NT-proBNP)水平与梗死后短期心力衰竭的关系。方法将80例AMI患者分为心力衰竭组和非心力衰竭组,测定入院时及入院后24 h、7 d的血浆NT-proBNP浓度及超声心动图检查的左室射血分数(LVEF)及左室舒张末内径(LVEDD),出院随访30 d。结果心力衰竭组血浆24 h、7 d NT-proBNP水平持续增高,两组在入院即刻及入院24 h、7 d时血浆NT-proBNP水平比较差异有统计学意义(P<0.01)。NT-proBNP水平与LVEF呈负相关(P<0.05),与LVEDD呈显著正相关(r=0.452,P<0.01)。结论血浆NT-proB-NP水平是心肌梗死后早期发生心力衰竭的预测因子,并有预后判断价值。

Relationship between NT-proBNP and short-term prognosis of heart failure in patients with acute myocardial infarction

Objective To investigate the relationship between serial NT-proBNP level and short-term prognosis of heart failure in acute myocardial infarction（AMI） patients.Methods Eighty patients with AMI were divided into two groups： heart failure group and non-heart failure group.The rapid plasma NT-proBNP levels were measured in all patients before treatment and at 24 hours,7 days after treatment.All patients were followed up after admission for 30 days.Results At admission and at 24 hours,7 days immediately,there were significant differences of NT-proBNP levels between the two groups（P0.05）.NT-proBNP levels in heart failure group increased significantly at 24 h,7 d days after admission（P0.01）.UCGs showed that LVEF and LVEDD in non-heart failure group were better than those in heart failure group at 7 days after admission.NT-proBNP level was negatively correlated with LVEF（r=-0.393,P0.01）,but was positively correlated with LVEDD（r=0.425,P0.01）.NT-proBNP levels at admission and at 24 hours,7 days were markedly correlated with the occurrence of heart failure events（P0.01）.Conclusion The plasma NT-BNP levels could be a predictor for occurrence of heart failure in AMI patients.