复方何首乌浸膏治疗阿尔茨海默病的疗效研究

目的：观察复方何首乌浸膏治疗阿尔茨海默病（AD）的临床疗效。方法：收集AD患者209例,其中复方何首乌治疗组120例,采用复方何首乌浸膏治疗;何首乌组(中药对照组)60例,采用单药何首乌浸膏治疗;西药对照组29例,采用脑复康片治疗,比较各组治疗12周前后简易精神状态量表(MMSE)、日常生活功能量表(ADL)的评分及临床疗效。结果：各组治疗后MMSE及ADL评分均较前改善,复方何首乌治疗组MMSE和ADL评分均明显优于中药与西药对照组,差异有统计学意义(P<0.01)。复方何首乌治疗组总有效率为93.33％,优于何首乌组的73.33％和西药对照组的68.97％。结论：复方何首乌浸膏治疗阿尔茨海默病的疗效优于单味中药何首乌与西药脑复康。

Effect of compound Polygonum multiflorum extract on Alzheimer's disease

ObjectiveTo observe the clinical effect of compound Polygonum multiflorum extract on Alzheimer’s disease (AD).MethodsWe collected 209 AD patients, among whom 120 were treated with compound Polygonum multiflorum extract as a treatment group, 60 were treated with Polygonum multiflorum extract as a Chinese herb control group, and 29 were treated with Naofukang as a western medicine control group. The scores for the Mini-Mental State Examination (MMSE),Ability of Daily Living Scale (ADL) and the therapeutic effect were assessed and compared before and after the 12 week treatment. ResultsAfter the treatment the scores for MMSE and ADL were improved in all groups. The scores of MMSE and ADL in the compound Polygonum multiflorum extract treatment group were significantly improved compared with the Chinese herb control group and the western medicine control group (P<0.01).The total effective rate of 93.33％in the compound Polygonum multiflorum extract treatment group was better than 73.33％ in the Chinese herb control group and 68.97％ in the western medicine control group (P<0.01). ConclusionCompound Polygonum multiflorum extract has effect on AD, and it is superior to Polygonum multiflorum extractor Naofukang.