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| 黄酮和黄烷酮-7-O-异丙醇胺衍生物的合成及抗心律失常活性 | |
| 引用本文： | 何晓树,杨福秋,雷兴翰,陈解春,闵旸. 黄酮和黄烷酮-7-O-异丙醇胺衍生物的合成及抗心律失常活性[J]. 中国药物化学杂志, 1990, 0(1) |
| 作者姓名： | 何晓树 杨福秋 雷兴翰 陈解春 闵旸 |
| 作者单位： | 上海医药工业研究院，上海医药工业研究院，上海医药工业研究院，上海医药工业研究院，上海医药工业研究院 上海 1988届博士研究生，上海，上海，上海，上海 |
| 摘 要： | 合成了五组B环具不同取代基的黄酮和黄烷酮-7-o-异丙醇胺衍生物,并进行了对乌头碱诱发大鼠室性心律失常预防作用的药理试验。有五个化合物呈现了良好的抗心律失常作用,初步分析了结构和活性的关系。 |
| 关 键 词： | 黄酮 黄烷酮 异丙醇胺衍生物 抗心律失常活性 |
SYNTHESIS OF FLAVONE AND FLAVANONE-7-O-ISOPROPANLAMINE DERIVATIVES AND THEIR ANTI-ARRHYTHMIC ACTIVITY |
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| He Xiaoshu,Yang Fuqiu,Lei Xinghan,Chen Jiechun,Min Yang. SYNTHESIS OF FLAVONE AND FLAVANONE-7-O-ISOPROPANLAMINE DERIVATIVES AND THEIR ANTI-ARRHYTHMIC ACTIVITY[J]. Chinese Journal of Medicinal Chemistry, 1990, 0(1) | |
| Authors: | He Xiaoshu Yang Fuqiu Lei Xinghan Chen Jiechun Min Yang |
| Affiliation: | He Xiaoshu,Yang Fuqiu~*,Lei Xinghan~*,Chen Jiechun,Min Yang |
| Abstract: | Five groups of B-ring substituted flavone and flavanone-7-O-isopropanolamine derivatives were synthesized and tested on rats for the ventricular arrhythmia induced by aconitine. Five compounds exerted a pronounced anti-arrhthmic activity. The structure-activity relationship was discussed, |
| Keywords: | Flavone Flavanone Isopropanolamine derivatives Antiarrhythmia activity. |
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