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Extra-pancreatic effects of Momordica charantia in rats
Authors:J Welihinda  E H Karunanayake
Affiliation:1. Key Laboratory of Bioactive Substances and Resource Utilization of Chinese Herbal Medicine, Ministry of Education, Institute of Medicinal Plant Development, Peking Union Medical College, Chinese Academy of Medical Sciences, Beijing 100193, People''s Republic of China;2. Center of Research and Development on Life Sciences and Environment Sciences, Harbin University of Commerce, Harbin 150076, China;3. Institute of Bioinformatics and Medical Engineering, School of Electrical and Information Engineering, Jiangsu University of Technology, Changzhou 213001, China;1. Department of Nutrition, University of North Carolina at Greensboro (UNCG), Greensboro, NC 27402, USA;2. Department of Kinesiology, UNCG, Greensboro, NC 27402, USA;3. Department of Pathology, Section on Lipid Sciences, Wake Forest School of Medicine, Winston-Salem, NC 27157, USA;4. Department of Statistics, UNCG, Greensboro, NC 27402, USA
Abstract:
The extra pancreatic effects of the oral hypoglycaemic plant Momordica charantia have been investigated in rats. It was found that the fruit juice of this plant caused an increased glucose uptake by tissues in vitro without concomitant increase of tissue respiration. Oral treatment with the juice prior to a glucose load was found to increase the glycogen content of liver and muscle while it had no effect on the triglyceride content of adipose tissue. Pretreatment of fasted rats with M. charantia fruit juice had no significant effect on the gluconeogenic capacity of kidney slices. Similar results were obtained with kidney slices pre-incubated with M. charantia fruit juice.
Keywords:
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