孕妇及高胆红素血症新生儿G6PD检测结果分析

目的 探讨产前及新生儿葡萄糖-6-磷酸脱氢酶(G6PD)活性检测的意义.方法 采用比值法检测4 000例孕妇产前血标本及其所分娩的787例高胆红素血症新生儿血标本.结果 4 000例孕妇G6PD缺乏症检出率为4.1%(164/4 000);787例高胆红素血症新生儿G6PD缺乏症发病率为13.8%(109/787).结论 本地区孕妇G6PD缺乏症发病率较高;G6PD缺乏症是引起新生儿溶血病的主要原因.孕妇产前和胎儿出生后进行G6PD活性检测有利于减少新生儿溶血病的发病率和提高治愈率.

Results analysis of G6PD detection in gravida and neonatus with hyperbilirubinemia

Objective To explore the significance of glucose-6-phosphate dehydrogenase(G6PD) detection in gravida and neonatus.Methods Ratio method was performed for to detect G6PD activity in blood specimens from 4 000 cases of gravida and 787 cases of neonatus with hyperbilirubinemia.Results The detection rate of G6PD deficiency was 4.1%(164/4 000) in gravida and 13.8%(109/787) in neonatus with hyperbilirubinemia.Conclusion In this area,the disease rate of G6PD deficiency might be relatively high in gravida,and G6PD deficiency might be the main etiological factor for neonatal hyperbilirubinemia.Detection of G6PD activity in gravida and neonatus might be useful for the prevention of hemolytic disease of newborn and increasing recovery rate.