黛力新对冠心病伴焦虑抑郁患者治疗效果和生活质量的影响

目的：探讨氟哌噻吨美利曲辛片（黛力新）与抗心肌缺血治疗对冠心病伴焦虑抑郁患者的疗效和对生活质量的影响。方法：冠心病伴焦虑抑郁患者128例，随机被均分为黛力新组（给予抗心肌缺血药物联合黛力新治疗）和常规治疗组（单纯抗心肌缺血治疗）。疗程4周时观察临床症状、心电图及焦虑自评量表和抑郁自评量表评分的变化；半年后采用中国心血管病人生活质量评定问卷进行生活质量评估。结果：黛力新组心绞痛和心电图总有效率分别为92．2％和84．4％，明显高于常规治疗组的79．7％和68．8％（P均〈0．05），黛力新组焦虑自评量表和抑郁自评量表评分在治疗后显著下降（P均〈0．01），且显著优于常规治疗组焦虑评分量表（39．65±7．22）分比（53．30±8．50）分，抑郁评分量表（42．23±8．92）分比（57．47±9．50）分，P均〈0．01]，常规治疗组治疗前后无显著变化（P均〉0．05）；黛力新组中国心血管病人生活质量评定问卷的各项得分均明显高于常规治疗组（P均〈0．01）。结论：黛力新治疗冠心病伴焦虑、抑郁患者效果好，能够改善患者的生活质量。

Effects of Deanxit on patients with coronary heart disease complicated anxiety and depression and their quality of life

Objective:To explore effects of flupentixol and melitracen tablets(Deanxit) and anti-ischemic therapy on patients with coronary heart disease(CHD) complicated anxiety and depression and their quality of life.Methods:A total of 128 CHD patients with anxiety and depression were randomly and equally divided into Deanxit group(anti-ischemic drugs combined Deanxit therapy) and routine treatment group(only received anti-ischemic therapy).Changes of echocardiogram(ECG) and scores of self-rating anxiety scale(SAS) and self-rating depression scale(SDS) were observed on fourth week;after half a year,Chinese questionnaire of quality of life in patients with cardiovascular disease(CQQC) was used to evaluate quality of life in all patients.Results:Total effective rates of angina pectoris and ECG were 92.2% and 84.4% respectively in Deanxit group,which were significantly higher than those of routine treatment group(79.7%,68.8%,P<0.05 both).After treatment,there were significant decrease in scores of SAS and SDS in Deanxit group(P<0.01 both),and they were significantly lower than those of routine treatment group,and they were not significant different in routine treatment group between before and after treatment(P>0.05);CQQC score of each item of Deanxit group was significantly higher than that of routine treatment group(P<0.01 all).Conclusion:Deanxit has good therapeutic effects on patients with coronary heart disease complicated anxiety and depression,and it can improve quality of life of patients.