阿莫西林/β-环糊精包合作用研究

 目的研究阿莫西林/β-环糊精的包合,寻找改善阿莫西林制剂性能的方法。方法利用紫外光谱法和相溶解度法研究水溶液中阿莫西林/β-环糊精包合作用。采用研磨法制备阿莫西林/β-环糊精包合物,并用差示热分析和X射线衍射验证包合物的形成。比较了阿莫西林和包合物的体外溶出速率。结果阿莫西林和β-环糊精能够形成稳定的包合物。当体系中β-环糊精的浓度为6.16×10^-3mol·L^-1时,阿莫西林的溶解度提高2.89倍。包舍物在10min内的体外溶出速率上升7.2倍。结论环糊精包合技术显著提高了阿莫西林的溶解度和溶出度。

Study on the inclusion complex of amoxicillin and β-cyclodextrin

OBJECTIVE The inclusion complex of amoxicillin/β-cyclodextrin was investigated to improve the performance of the amoxi-cillin preparation. METHODS In aqueous solution, the inclusion complex of amoxicillin/β-cyclodextrin was studied by Ultraviolet Spec-troscopy and phase solubility. The inclusion complex was prepared by trituration and was confirmed by DTA and X-ray diffraction.The dissolution rates of amoxicillin and inclusion complex were compared. RESULTS In aqueous solution, inclusion complex easily formed between amoxicillin and β-cyclodextrin. In the presence of 6.16×10^-3 mol·L^-1 β-cyclodextrin,the solubility of inclusion complex was 3.89 times than that of amoxicillin.The dissolution rate in 10 minutes was 8.2 times as much as that of amoxicillin.CONCLUSION The solubility and dissolution of amoxicillin were improved with β-cyclodextrin.