Azithromycin resistance and its molecular characteristics in Neisseria gonorrhoeae isolates from a tertiary care centre in North India期刊界 All Journals 搜尽天下杂志传播学术成果专业期刊搜索期刊信息化学术搜索

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Azithromycin resistance and its molecular characteristics in Neisseria gonorrhoeae isolates from a tertiary care centre in North India

Authors:	Apoorva Challa Neeraj Mahajan Seema Sood Arti Kapil Bimal Kumar Das Vishnubhatla Sreenivas Somesh Gupta

Institution:	1. Department of Dermatology and Venereology, All India Institute of Medical Sciences, New Delhi 110029, India;2. Department of Microbiology, All India Institute of Medical Sciences, New Delhi 110029, India;3. Department of Biostatistics, All India Institute of Medical Sciences, New Delhi 110029, India;1. Department of Microbiology, Maulana Azad Medical College, New Delhi, 110002, India;2. Department of Pediatrics, Maulana Azad Medical College, New Delhi, 110002, India;1. Department of Microbiology, Pondicherry Institute of Medical Sciences, Kalapet, Puducherry - 605014, India;2. Department of Nephrology, Sri Naryani Hospital and Research Centre, Vellore - 632255, India;3. Department of Nephrology, JIPMER, Pondicherry - 605006, India;4. Department of Microbiology, The Madras Medical Mission, 4-A, Dr, Mogappair, Chennai - 600037, Tamil Nadu, India;5. Department of Nephrology, The Madras Medical Mission, 4-A, Dr, Mogappair, Chennai - 600037, Tamil Nadu, India;1. Department of Clinical Laboratory, Liaocheng People''s Hospital, No. 67, Dongchangxi Road, Dongchangfu District, Liaocheng 252000, Shandong Province, People''s Republic of China;2. Department Hepatobiliary Surgery, Liaocheng People''s Hospital, No. 67, Dongchangxi Road, Dongchangfu District, Liaocheng 252000, Shandong Province, People''s Republic of China;3. Department Pediatrics, Liaocheng People''s Hospital, No. 67, Dongchangxi Road, Dongchangfu District, Liaocheng 252000, Shandong Province, People''s Republic of China;1. Department of Biology, Qom Branch, Islamic Azad University, Qom, Iran;2. Department of Virology, Faculty of Medicine, Iran University of Medical Sciences, Tehran, Iran

Abstract:	Treatment guidelines for management of uncomplicated gonorrhoeae have been recently modified owing to alarming upsurge in azithromycin resistance. This study investigated the prevalence and genetic determinants of gonococcal azithromycin resistance in India. Four (5.7%) of 70 gonococcal isolates were resistant to azithromycin. Of 16 isolates investigated for molecular mechanisms of resistance, 13 (81.3%) and 6 (37.5%) isolates exhibited mutations in coding and promoter regions of mtrR gene, respectively. However, ermA, ermB and ermC genes or mutations in rrl gene were absent in all isolates. Azithromycin resistance is low in India posing no immediate threat to use of dual-therapy for syndromic management.

Keywords:	Antimicrobial resistance India
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