百令胶囊对老年慢性阻塞性肺疾病患者急性加重期的肺功能及T细胞免疫影响

目的 探讨百令胶囊干预治疗老年慢性阻塞性肺疾病(COPD)患者急性加重期T细胞免疫功能及肺功能的改变及.方法采用随机的方法将62例老年COPD住院患者分为老年COPD干预组32例、老年COPD未干预组30例,另有健康老年组28例.老年COPD干预组口服百令胶囊.检测三组患者外周血CD4+、CD8+、CD4+/CD8+的改变,同时观察老年COPD组的肺功能改善情况.结果干预组治疗第1个月后CD4+/CD8+差异有统计学意义(t=2.92,P＜0.05),而第3个月后CD4+上升,CD8+下降更明显,CD4+/CD8+大致恢复正常,与治疗前比较,差异均有统计学意义(t分别=5.22、3.53、4.74,P均＜ 0.05).而与非干预组治疗后第3个月CD4+、CD8+、CD4+/CD8+比较,差异均无统计学意义(t分别=0.75、0.83、1.21,P均＞0.05).干预组治疗后3个月与健康老年组比较,CD4+、CD8+、CD4+/CD8+差异均有统计学意义(t分别=2.03、2.04、2.25,P均＜0.05),而非干预组治疗后3个月与健康老年组比较,CD4+、CD8+、CD4+/CD8+差异均有统计学意义(t分别=8.19、4.36、6.34,P均＜0.05).在治疗3个月后两组FEV1/FVC%比较,差异有统计学意义( t=2.85,P＜0.05),而FVC、FEV1 比较,差异无统计学意义(t分别=0.35、1.24,P均＞0.05);干预组的FVC、FEV1、FEV1/FVC与治疗前比较,差异均有统计学意义(t分别=2.10、6.84、9.65,P均＜0.05).结论老年COPD患者在急性加重期细胞免疫功能下降,辅助应用百令胶囊,可改善其肺功能和细胞免疫功能.

Effects of Bailing capsule on lung function and immunological function of T-lymphocyte in the elderly patients with chronic obstructive pulmonary disease during acute exacerbations

Objective To investigate the immune responses and the clinical efficacy of Bailing capsule in elderly patients with chronic obstructive pulmonary disease（COPD） during acute exacerbations.Methods Sixty two patients with elderly COPD during acute exacerbations were selected and randomly divided into 2 groups：32 patients with general treatment adding Bailing capsule as an intervention group and 30 patients with general treatment as an non-intervention group.Another 28 healthy individuals served as the healthy elderly control.The clinical efficacy as well as the improvement of lung function and the changes in the immune function（mainly T-lymphocyte subset change）before and after treatment in all groups were observed.Results At 3 months post-treatment,increased CD4＋,decreased CD8＋,inversed ratio of CD4＋/CD8＋ were observed in patients with COPD（t=5.22,3.53,4.74,P〈0.05）.However,there were no significant change in non-intervention group（t=0.75,0.83,1.21,P〈0.05）.In comparison with the healthy group,there were significant difference in CD4＋,CD8＋ and ratio of CD4＋/CD8＋ in both intervention group（t=2.03,2.04,2.25,P〈0.05） and non-intervention group（t=8.19,4.36,6.34,P〈0.05）.The ratio of FEV1/FVC in intervention group was higher than that of non-intervention group（t=2.85,P〈0.05）.In the patients with intervention,FVC,FEV1,the ratio of FEV1/FVC post-treatment improved compared with that pre-treatment（t=2.10,6.84,9.65,P〈0.05）.Conclusions Immunological function is suppressed in elderly patients with COPD during acute exacerbations.The general treatment adding Bailing capsule can improve the lung function and enhance the lymphocyte immunological function.