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| 局灶性脑缺血再灌注模型大鼠脑SOD和MDA的变化 | |
| 引用本文： | 郑晓影,赵淑敏,陈萌,李涵. 局灶性脑缺血再灌注模型大鼠脑SOD和MDA的变化[J]. 承德医学院学报, 2009, 26(1) |
| 作者姓名： | 郑晓影 赵淑敏 陈萌 李涵 |
| 作者单位： | 1. 承德医学院,河北,承德,067000 2. 承德市解放军第266医院 |
| 基金项目： | 河北省科技厅资助项目 |
| 摘 要： | 目的:观察局灶性脑缺血再灌注大鼠模型脑超氧化物歧化酶(SOD)活性和丙二醛(MDA)含量的变化.方法:用线栓法建立大鼠局灶性脑缺血再灌注模型,TTC染色显示梗死范围;测定再灌注损伤脑组织中SOD活性和MDA含量.结果:与假手术组相比,模型组脑组织SOD活性显著降低、MDA含量明显增加(P<0.01).结论:局灶性脑缺血再灌注能显著降低再灌注损伤脑组织SOD活性,增加MDA含量. |
| 关 键 词： | 线栓法 SD大鼠 局灶性脑缺血再灌注 |
CHANGES OF SOD AND MDA IN BRAIN OF FOCAL CEREBRAL ISCHEMIA-REPERFUSION MODEL RATS |
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| ZHENG Xiao-ying,ZHAO Shu-min,CHEN Meng,et al. CHANGES OF SOD AND MDA IN BRAIN OF FOCAL CEREBRAL ISCHEMIA-REPERFUSION MODEL RATS[J]. Journal of Chengde Medical College, 2009, 26(1) | |
| Authors: | ZHENG Xiao-ying ZHAO Shu-min CHEN Meng et al |
| Affiliation: | ZHENG Xiao-ying,ZHAO Shu-min,CHEN Meng,et al (Chengde Medical College,Heibei Chengde 067000,China) |
| Abstract: | Objective:To observe the changes of superoxide dismutase(SOD)and malondialdehyde(MDA) in brain of focal cerebral ischemia-reperfusion model rats.Methods:The focal cerebral ischemia-reperfusion model rats were established by suture embolic method.TCC was used to display infraction scope;the SOD activity and MDA content in reperfusion injury brain were measured.Results:Compared with control group,in focal cerebral ischemia-reperfusion rats model brain,the SOD activity decreased and MDA content increased obvio... |
| Keywords: | SOD MDA |
| 本文献已被 CNKI 维普 万方数据 等数据库收录！ | |