An embryologic explanation for the corrected transposition of the great vessels: additional description of the main anatomic features of this malformation and its varieties |
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| Authors: | DE LA CRUZ M V ANSELMI G CISNEROS F REINHOLD M PORTILLO B ESPINO-VELA J |
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| Affiliation: | 1. Department of Anatomy and Cell Biology, University of Iowa, Iowa City, IA, United States of America;2. Center for Coronary Artery Anomalies at Texas Heart Institute, Baylor College of Medicine, Houston, TX, United States of America;1. Department of Applied Social Sciences, The Hong Kong Polytechnic University, Hong Kong;2. College of Teacher Education, Dali University, Dali, China;1. Infection Prevention and Health System Epidemiology, Atrium Health Wake Forest Baptist, Winston-Salem, NC;2. Department of Biostatistics and Data Science, Wake Forest School of Medicine, Winston-Salem, NC |
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| Abstract: | ![]()
- 1.1. The authors have reviewed the normal development of the bulboventricular loop, the ventricles, and the great vessels in the human embryo.
- 2.2. Corrected transposition of the great vessels in any of its varieties is a complex malformation in which two embryonic elements are involved: the bulboventricular loop and the truncoconal septum.
- 3.3. An embryologic explanation for the different varieties of corrected transposition of the great vessels is proposed. The anatomic features of all these varieties (in normally situated heart, in mirror-image dextrocardia, in one type of levocardia, and in the case of dextrorotation) are also given.
- 4.4. A new theory based on recent embryologic findings is offered to explain the development of corrected transpositions of the great vessels.
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