未破型输卵管妊娠保守治疗后重复异位妊娠37例分析

[目的]探讨未破型输卵管妊娠保守治疗后,重复异位妊娠的危险因素及3种不同保守治疗方式对重复异位妊娠的影响。[方法]回顾分析2002年1月~2009年1月某院诊断为未破型输卵管妊娠患者198例,分别采用单纯MTX化疗、开放手术及腹腔镜手术3种保守治疗方式治疗成功,追踪其生育结局12~72个月,根据生育结局分为重复异位妊娠组和宫内妊娠组,根据治疗方式分为MTX组,开放组和腹腔镜组。[结果]①37例(18.7%)患者发生重复异位妊娠,其中MTX化疗后17例,开放手术后12例,腹腔镜手术后8例。②异位妊娠组中存在不良孕产史、盆腔感染、盆腔粘连的患者分别占91.9%、91.9%和75.8%。③3种治疗方式异位妊娠发生率分别为16.8%、37.5%和12.3%,其中药物治疗组和腹腔镜手术组均与开放手术组差异有统计学意义,药物治疗组与腹腔镜组手术组之间差异无统计学意义。[结论]输卵管炎史、不良孕产史、盆腔粘连等因素可增加重复异位妊娠的发生,未破裂型输卵管妊娠可行药物治疗或腹腔镜下保守性手术作为保留生育功能患者的首选治疗方式,且不增加重复异位妊振的发生率。

ANALYSIS OF 37 CASES OF REPEAT ECTOPIC PREGNANCY AFTER CONSERVATIVE THERAPY FOR UNRUPTURED TUBAL PREGNANCY

[Objective]To explore the risk factors of repeat ectopic pregnancy after conservative therapy for unruptured tubal pregnancy and the effect of three conservative therapies on repeat ectopic pregnancy.[Methods]We retrospectively analyzed 198 patients diagnosed as unruptured tubal pregnancy from Jan. 2002 to Jan. 2009,who got successful treatment respectively by MTX chemotherapy,open surgery and laparoscopic surgery. They were divided into repeat ectopic pregnancy group and uterine pregnancy group according t...