| 吉西他滨与奥沙利铂联合化疗治疗晚期膀胱癌的疗效和不良反应 |
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| 引用本文： | 张治业,高晓会,郭双双,姚俊,郭艳珍,张殿宝.吉西他滨与奥沙利铂联合化疗治疗晚期膀胱癌的疗效和不良反应[J].现代预防医学,2011,38(16):3385-3386,3389. |
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| 作者姓名： | 张治业 高晓会 郭双双 姚俊 郭艳珍 张殿宝 |
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| 作者单位： | 河南科技大学第一附属医院肿瘤内科,洛阳,471003 |
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| 摘 要： | 目的]探讨吉西他滨联合奥沙利铂方案治疗晚期膀胱癌的疗效及不良反应。方法]56例Ⅳ期膀胱癌接受吉西他滨联合奥沙利铂方案化疗:吉西他滨1000mg/m2,d1和d8,奥沙利铂135mg/m2,d1;21d为1个周期,每2疗程评价疗效。结果]本组65例晚期膀胱癌患者完全缓解(CR)3例(5.36%),部分缓解(PR)27例(48.21%),总有效率(CR+PR)43.57%。在疼痛缓解、全身情况明显改善,生存质量和KPS评分提高等方面均取得了较好疗效。主要不良反应为骨髓抑制、外周神经毒性、消化道反应等。无治疗相关死亡者。结论]吉西他滨与奥沙利铂联合化疗是治疗晚期膀胱癌的有效方法,并且毒副反应相对较轻。
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| 关 键 词： | 吉西他滨 奥沙利铂 膀胱癌 |
CURATIVE EFFECT AND ADVERSE REACTIONS OF GEMCITABINE COMBINED WITH OXALIPLATIN IN TREATMENT OF LATE BLADDER CANCER |
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| ZHANG Zhi-ye,GAO Xiao-hui,GUO Shuang-shuang,et al..CURATIVE EFFECT AND ADVERSE REACTIONS OF GEMCITABINE COMBINED WITH OXALIPLATIN IN TREATMENT OF LATE BLADDER CANCER[J].Modern Preventive Medicine,2011,38(16):3385-3386,3389. |
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| Authors: | ZHANG Zhi-ye GAO Xiao-hui GUO Shuang-shuang |
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| Institution: | ZHANG Zhi-ye,GAO Xiao-hui,GUO Shuang-shuang,et al.(Department of Oncology,the First Affiliated Hospital of Henan University of Technology,Luoyang 471003,China) |
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| Abstract: | Objective]To evaluate the efficiency and adverse reactions of gemcitabine combined with oxaliplatin in treatment of later bladder cancer.Methods]56 patients with metastatic bladder cancer were treated with gemcitabine 1 000 mg/m2 on d1,d8 and L-OHP 135mg/m2 on d1,and every 21 days as one cycle. After two consecutive treatment courses,the evaluation of the short term efficacy and adverse effects was carried out.Results]65 patients were evaluable for response. Major objective responses were observed in 30 ... |
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| Keywords: | Gemcitabine Oxaliplatin Bladder cancer |
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