宫颈癌危险因素的Meta分析

[目的]运用Meta分析方法综合分析评价宫颈癌致病危险因素。[方法]本文收集国内有关宫颈癌危险因素的病例对照研究文献20篇,采用可信区间方差分析法计算各相关因素的ORc及95%CI。[结果]口服避孕药的ORc的95%CI包括1,其他相关因素的ORc的95%CI不包括1。[结论]文化程度、家庭收入、首次性生活年龄、首次怀孕年龄、首次生育年龄、首次结婚年龄、绝经情况和职业是宫颈癌的保护因素,HPV感染、多孕、多产、多婚、性伴数、重大精神创伤、慢性宫颈炎、包皮过长、恶性肿瘤史和吸烟是宫颈癌的危险因素。口服避孕药与宫颈癌关系尚不明确,需进一步研究。吸烟、慢性宫颈炎、多婚、首次生育年龄等因素结果存在较大偏性,与宫颈癌的关系尚需进一步证实。

META-ANALYSIS OF RISK FACTORS OF CERVICAL CANCER

[Objective]To study the risk factors for cervical cancer in China by Meta-analysis.[Methods]The results from 20 literature about case-control studies on risk factors for cervical cancer were analyzed quantitatively and synthetically by Meta-analysis,and the ORc and 95%CI was computed.[Results]The ORc(95%CI)of the oral contraceptives included 1,and the other related factors of ORc(95%CI)did not include 1.[Conclusion]The protective factors influencing the incidence of cervical cancer among Chinese female were...