|
|||||
|
|
| 海南省百岁人群中CETP基因多态性研究 | |
| 引用本文： | 张云霞,周代锋,焦解歌,范平毅,李美英,彭存智,蔡苗,麦明晓,蔡望伟. 海南省百岁人群中CETP基因多态性研究[J]. 现代预防医学, 2011, 38(16): 3273-3274,3277 |
| 作者姓名： | 张云霞 周代锋 焦解歌 范平毅 李美英 彭存智 蔡苗 麦明晓 蔡望伟 |
| 作者单位： | 海南医学院中国热带农业科学院生物技术研究所,海口,571101 |
| 基金项目： | 海南省科技计划资助项目，海南医学院生物化学与分子生物学重点学科资项目，海南省老龄办资助项目 |
| 摘 要： | [目的]了解海南省百岁人群中CETP基因I405V和TaqIB突变位点的多态性。[方法]收集海南省276例百岁老人全血DNA,利用AS-PCR结合测序的方法检测CETP基因I405V及TaqIB突变位点的多态性。[结果]I405V多态位点II、IV、VV3种基因型频率分别为28.6%、55%、16.3%,I和V的等位基因频率分布为56.2%和43.8%。TaqIB位点B1B1、B1B2、B2B23种基因型的发生率10.7%,73.6%,19.4%,B1和B2等位基因频率分布为47.3%和52.7%。[结论]海南百岁人群中CETP基因I405V和TaqIB多态性与已报道的海南汉族普通人群存在明显差异,可能与海南长寿密切相关。 |
| 关 键 词： | 百岁老人 CETP基因多态性 I405V突变位点 TaqIB突变位点 |
THE POLYMORPHISM OF POLYMORPHISM OF CETP GENE IN CENTENARIANS OF HAINAN PROVINCE |
|
| ZHANG Yun-xia,ZHOU Dai-feng,JIAO Jie-ge,et al.. THE POLYMORPHISM OF POLYMORPHISM OF CETP GENE IN CENTENARIANS OF HAINAN PROVINCE[J]. Modern Preventive Medicine, 2011, 38(16): 3273-3274,3277 | |
| Authors: | ZHANG Yun-xia ZHOU Dai-feng JIAO Jie-ge et al. |
| Affiliation: | ZHANG Yun-xia,ZHOU Dai-feng,JIAO Jie-ge,et al.(Tropical Chinese Academy of Agricultural Biotechnology Research Institute,Hainan Medical University,Haikou 571101,China) |
| Abstract: | [Objective]To understand the polymorphism of CETP gene in centenarians of Hainan province.[Methods]The two polymorphic locus of CETP gene was probed with an allele specific-PCR(AS-PCR)in 276 centenarians of Hainan province.[Results]Three genotypes were detected in I405V locus witch,and the frequencies of II,IV,and VV genotypes were 28.6%,55% and 16.3%,respectively. The frequencies of allele I and V were 56.2% and 43.8%,respectively. Frequencies of B1B1,B1B2 and B2B2 in TaqIB locus were 10.7%,73.6% and 19.4%... |
| Keywords: | Centenarian Polymorphism of cholesterol ester transfer protein(CETP)gene I405V TaqIB |
| 本文献已被 CNKI 万方数据 等数据库收录！ | |