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| 微波消融治疗对原发性肝癌患者血清VEGF表达影响及临床意义 | |
| 引用本文： | 周思朗,陈永乐,彭心昭,赵永星,谢培增,凌龙,陈晓文,戴凯明. 微波消融治疗对原发性肝癌患者血清VEGF表达影响及临床意义[J]. 现代预防医学, 2011, 38(17): 3598-3599,3601 |
| 作者姓名： | 周思朗 陈永乐 彭心昭 赵永星 谢培增 凌龙 陈晓文 戴凯明 |
| 作者单位： | 解放军第四二一医院肿瘤科,广州,510318 |
| 摘 要： | [目的]观察微波消融治疗原发性肝癌(PHC)对血清血管内皮生长因子(VEGF)的影响。[方法]采用ELISA方法测定60例PHC患者微波消融治疗前后和60例健康查体者血清VEGF水平。[结果]PHC组治疗前和治疗后血清VEGF水平均显著高于对照组,相比较差异有统计学意义(P﹤0.05);PHC组治疗后3d血清VEGF水平显著上升,治疗后7d血清VEGF水平显著下降,与治疗前比较有显著性差异(P﹤0.05);VEGF在不同年龄、性别、肿瘤直径大小患者血清中的表达差异无统计学意义(P﹥0.05),而VEGF水平在不同的临床分期、肿瘤远处转移与否之间比较差异有统计学意义(P﹤0.05)。[结论]微波消融治疗PHC可通过抑制VEGF的表达来达到抑制肿瘤生长和转移,血清VEGF水平可作为评估微波消融治疗的临床疗效及肿瘤残存、复发、转移的一个有效的预测指标。 |
| 关 键 词： | 原发性肝癌 微波消融治疗 血管内皮生长因子 |
EFFECT ON SERUM VEGF EXPRESSION IN PATIENTS WITH PRIMARY HEPATOCELLUo LAR CARCINOMA BY MIEROWAVE ABLATION THERAPY AND CLINICAL SIGNIFICANCE OF VEGF EXPRESSION |
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| ZHOU Si-lang,CHEN Yong-le,PENG Xin-zhao,et al.. EFFECT ON SERUM VEGF EXPRESSION IN PATIENTS WITH PRIMARY HEPATOCELLUo LAR CARCINOMA BY MIEROWAVE ABLATION THERAPY AND CLINICAL SIGNIFICANCE OF VEGF EXPRESSION[J]. Modern Preventive Medicine, 2011, 38(17): 3598-3599,3601 | |
| Authors: | ZHOU Si-lang CHEN Yong-le PENG Xin-zhao et al. |
| Affiliation: | ZHOU Si-lang,CHEN Yong-le,PENG Xin-zhao,et al.(Department of Oncology,421 Hospital of PLA,Guangzhou 510318,China) |
| Abstract: | [Objective]To observe the effect on serum vascular endothelial growth factor(VEGF)expression in patients with primary hepatocellular carcinoma(PHC)by mierowave ablation therapy and clinical significance of VEGF expression.[Methods]The serum VEGF level of 60 patients with PHC before and after microwave ablation therapy,and 60 healthy people were determined by ELISA.[Results]Before and after microwave ablation therapy,the serum VEGF levels of the PHC group were significantly higher than the control group,the ... |
| Keywords: | Primary hepatocellular carcinoma Mierowave ablation therapy VEGF |
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