| 虎杖煎剂对大鼠实验性肝损伤的保护作用 |
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| 引用本文： | 罗德生,郑红花,刘琴,罗丽芳,李映红,王梅娟. 虎杖煎剂对大鼠实验性肝损伤的保护作用[J]. 咸宁医学院学报, 2000, 14(4): 229-231 |
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| 作者姓名： | 罗德生 郑红花 刘琴 罗丽芳 李映红 王梅娟 |
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| 作者单位： | 咸宁医学院生物化学教研室,咸宁 |
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| 基金项目： | 湖北省教育厅教研资助课题! (972 47) |
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| 摘 要： | 目的：研究虎杖煎剂对大白鼠实验性肝损伤的保护作用及其机制。方法：采用急性ＣＣｌ４肝损伤模型，实验设虎杖煎剂大、中、小剂量治疗组、对照组和正常组，观察各组大白鼠血浆中丙二醛（ＭＤＡ）含量及超氧化物歧化酶（ＳＯＤ）、山梨醇脱氢酶（ＳＤＨ）活性变化。结果：虎杖煎剂三个剂量治疗组均能降低血ＭＤＡ含量和ＳＤＨ活性，增加ＳＯＤ活性，减轻肝损伤程度。中剂量效果最佳。结论：虎杖煎剂具有良好的保护ＣＣｌ４致大鼠急性
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| 关 键 词： | 急性肝损伤 大鼠 中医药治疗 虎杖煎剂 |
| 文章编号： | 1008－0635(2000)04－0229－03 |
| 修稿时间： | 2000-07-13 |
Protective Effect of Polygoni on Experimental Liver Injury in Wistar Rats |
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| LUO Desheng ,ZHENG Honghua ,LIU Qin et al Biochemical. Protective Effect of Polygoni on Experimental Liver Injury in Wistar Rats[J]. Journal of Xianning Medical College, 2000, 14(4): 229-231 |
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| Authors: | LUO Desheng ZHENG Honghua LIU Qin et al Biochemical |
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| Affiliation: | LUO Desheng 1,ZHENG Honghua 1,LIU Qin 2 et al 1 Biochemical Department of Xianning Medical College,Xianning 437100 2 Heath School of Huangshi City of Hubei,Huangshi 435000$$$$ |
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| Abstract: | Objective To research the protective effect of polygoni on liver injury induced by perchlormethane.Method The liver injury was induced by perchlormethane,then the animals were divided into four groups-three of them treated by of polygoni high,middle and low dosage espectively,and the another one as control without treatment.The SDH,SOD activities and MDA level in serum were measured for each group.Results In all groups treated with polygoni especially in middle dosage the MDA level and SDH activity were obviously decreased.Conclusion Polygoni has good protective effect on acute liver injury by perchlormethane,the mechanism may be relating to inhibiting the lipid peroxidation. |
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| Keywords: | Polygoni Acute liver injury |
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