Chromosomal Mapping of Genetic Locus Associated with Thymus-size Enlargement in BUF/Mna Rats |
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| Authors: | Yoshiki Murakumo Masahide Takahashi Atsushi Arakawa Mitsuhiro Saito Hiroyuki Amo Hideki Katoh Mutsushi Matsuyama |
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| Affiliation: | Department of Pathology, Nagoya University School of Medicine, 65 Tsurumai-cho, Showa-ku, Nagoya 466;Department of Obstetrics and Gynecology, Nagoya City University Medical School, 1 Kawasumi, Mizuho-cho, Mizuho-ku, Nagoya 467;Aichi Women's College, 57 Takenoyama, Iwasaki, Nisshin-cho, Aichi-gun, Aichi-ken 470–01;Central Institute for Experimental Animals, 1430 Nogawa, Miyamae-ku, Kawasaki 213 |
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| Abstract: | The thymoma-prone rat of the BUF/Mna strain is a useful model for human thymoma. In this strain thymoma development is regulated by a single autosomal susceptible gene, Tsr-1. At pre-thymoma age, BUF/Mna rats have extremely large thyrauses, when compared to those of other strains of rats. Genetic studies in crosses between BUF/Mna rats with large thymuses and WKY/NCrj rats with small thymuses suggested the presence of a major autosomal gene, Ten-1 , which contributes to thymus enlargement in a backcross population. Linkage studies between Ten-1 and microsatellite markers in backcross rats of (WKY/NCrj×BUF/Mna)Fl×BUF/Mna have led to the localization of Ten-1 in chromosome 1. This result may provide an approach to clone Tsr-1 , which could be allelic to Ten-1. |
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| Keywords: | Ten-1 Large thymus Chromosome 1 BUF/Mna rat Tsr-1 |
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