| 丹酚酸B与三七总皂苷不同配比对大鼠离体心脏冠脉流量的影响 |
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| 引用本文： | 李玉红,;徐强,;高秀梅,;胡利民,;张伯礼. 丹酚酸B与三七总皂苷不同配比对大鼠离体心脏冠脉流量的影响[J]. 天津中医学院学报, 2008, 0(4): 261-262 |
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| 作者姓名： | 李玉红, 徐强, 高秀梅, 胡利民, 张伯礼 |
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| 作者单位： | 天津中医药大学中医药研究院，天津市中药药理学重点实验室，天津中医药大学第二附属医院 |
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| 基金项目： | 国家重点基础研究发展计划973计划课题（2005CB523404）. |
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| 摘 要： | 【目的】探讨丹酚酸B、三七总皂苷协同应用对大鼠离体心脏冠脉流量的影响。【方法】应用均匀设计的方法，将丹酚酸B与三七总皂苷的不同配比设计为6个水平，应用Langendorff系统进行离体心脏恒压灌流。记录6组实验给药前后大鼠的冠脉流量。【结果】丹酚酸B与三七总皂苷在升高大鼠冠脉流量上不存在线性回归关系．6组实验中以1号实验丹酚酸B／三七总皂苷为20mg／30mg升高大鼠冠脉流量最佳。【结论】丹酚酸B、三七总皂苷协同应用对大鼠离体心脏冠脉流量有很大影响。
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| 关 键 词： | 丹酚酸B 三七总皂苷 离体心脏 |
Effect of different matching of salvianolic Acid B and panax Pseudo-ginseng total saponin on coronary artery flow of isolated heart in rats |
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| Affiliation: | LI Yu-hong, XU Qiang, GAO Xiu-mei, et al (Tianjin University of TCM, Tianjin Key Laboratory of Chinese Medicine Pharmacology, Tianjin 300193, China) |
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| Abstract: | [Objective] To explore the effect of different matching of salvianolic acid B combined with and panax pseudo-ginseng total saponin on coronary artery flow of isolated heart in rats. [Methods] Six levels of different matching of salvianolic acid B and panax pseudo-ginseng total saponin were designed. Constant pressure perfusion of isolated heart was carried out by using Langendorff system and the coronary artery flow rate was recorded. [Results] There wasn＇t linear regression relation in enhancing coronary artery flow rate when salvianolic acid B and panax pseudo-ginseng total saponin were used. The 20 mg：30 mg dosage group was the best for increasing the coronary artery flow rate in rats. [Conclusion] Different matching of salvianolie acid B and panax pseudo-ginseng total saponin has a tremendous effect on coronary artery flow rate of isolated heart in rats. |
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| Keywords: | salvianolic acid B panax pseudo-ginseng total saponin isolated heart |
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