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| 血清ANCA检测对肾脏疾病患者的诊断意义 | |
| 引用本文： | 符克英,陈汝,钟路,詹锋. 血清ANCA检测对肾脏疾病患者的诊断意义[J]. 中国热带医学, 2006, 6(2): 294-295 |
| 作者姓名： | 符克英 陈汝 钟路 詹锋 |
| 作者单位： | 海南省人民医院肾病研究室,海南,海口,570311 |
| 摘 要： | 目的 进一步探讨血清中的抗中性粒细胞胞浆抗体（ANCA）检测在肾脏疾病患者中的诊断意义。方法 应用间接免疫荧光（IIF）和ELISA方法检测了205例肾脏疾病患者血清中的ANCA及其靶抗原。结果 在205例肾脏痰病患者血清中，ANCA阳性40例占19．5％，其中38例为pANCA阳性（38／205）；2例为eANCA阳性（2／205）。结论 不同ANCA荧光模型与疾病种类及预后密切相关；提高pANCA与ANA荧光模型的鉴别，有助于血管炎与其它自身免疫性疾病的诊断；同时应用IIF和ELISA方法检测ANCA，可以提高ANCA检测结果的可靠性。 |
| 关 键 词： | 抗中性粒细胞胞浆抗体 间接免疫荧光 肾脏疾病 |
| 文章编号： | 1009-9727(2006)02-294-02 |
| 收稿时间： | 2005-11-07 |
| 修稿时间： | 2005-11-07 |
The significance of detection of ANCA from serum in diagnosis of nephropathy |
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| FU Ke - ying, CHEN Ru, ZHONG Lu,et al.. The significance of detection of ANCA from serum in diagnosis of nephropathy[J]. China Tropical Medicine, 2006, 6(2): 294-295 | |
| Authors: | FU Ke - ying CHEN Ru ZHONG Lu et al. |
| Affiliation: | FU Ke - ying, CHEN Ru, ZHONG Lu, et al. |
| Abstract: | Objective To further explore the significance of serum antineutrophil cytoplasmic antibodies(ANCA) in renal diseases. Methods ANCA fluorescent patterns and its target antigens in sera of 205 patients with renal diseases were determined by indirect immunofluorescence(IIF) and ELISA. Results The positive percentage of ANCA is 19.5%(40/205),in which 18.5%(38/205) pANCA and 1%(2/205) cANCA. Conclusion The different fluorescent patterns are correlated closely with kinds and prognosis of diseases.Differentiating fluorescent patterns between pANCA and ANA helps to the diagnosis between vasculitis and other autoimmune diseases.Detecting ANCA by IIF and ELISA simultaneously can increase the reliability of the results of ANCA. |
| Keywords: | ELISA |
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