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LRRK2 and Parkin mutations in a family with parkinsonism-Lack of genotype-phenotype correlation |
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| Authors: | Marras Connie Klein Christine Lang Anthony E Wakutani Yosuke Moreno Danielle Sato Christine Yip Edwin Munhoz Renato P Lohmann Katja Djarmati Ana Bi Andrew Rogaeva Ekaterina |
| Affiliation: | Movement Disorders Centre, Toronto Western Hospital, Toronto, Canada. Connie.marras@utoronto.ca |
| Abstract: | Here we report the relationship between age at onset, clinical course and genotype in a family with combined LRRK2 G2019S and Parkin exon 2 deletions. In the combined mutation carriers the age at onset and clinical course was highly variable and not always younger than in the carriers of LRRK2 G2019S mutations alone. |
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