视神经胶质瘤的诊治研究现状及进展

视神经胶质瘤（ONG）是一种好发于儿童和青少年且相对罕见的中枢神经系统肿瘤，主要病理类型为低级别的毛细胞型星形细胞瘤。其分为散发和1型神经纤维瘤病（NF-1）相关的ONG。由于ONG与视神经的紧密关系，在诊疗上存在其特殊性，其诊断主要依靠病史、症状和体征，以及磁共振成像和CT等影像检查。ONG应与神经鞘脑膜瘤、视神经炎...

Progress and controversy in diagnosis and treatment of optic nerve gliomas

Optic nerve glioma(ONG)is a rare central nervous system tumor that occurs in children and adolescents.It’s main pathological type is low-grade pilocytic astrocytoma.It is divided into sporadic ONG and neurofibromatosis type 1(NF-1)related ONG.Due to the close relationship between ONG and the optic nerve,there is its particularity in diagnosis and treatment.The diagnosis of ONG mainly relies on medical history,symptoms and signs,as well as imaging examinations such as MRI and CT.ONG should be differentiated from optic nerve sheath meningioma,optic neuritis,optic nerve metastasis and other diseases.In recent years,newly discovered molecular targeted therapy and anti-vascular endothelial growth factor drugs are a powerful supplement to ONG.When chemotherapy is not sensitive or resistant,radiotherapy can be considered,but it is only recommended for patients over 7 years of age.Surgery can be considered when the patient’s visual impairment is severe and the appearance of the eye is significantly affected.In addition,due to the susceptibility of NF-1 patients to tumors,the chemotherapy regimen should take into account the risk of secondary leukemia caused by the drug,and the timing of radiotherapy should be after the age of 10.We look forward to further ONG clinical research,which will bring more references for future clinical work.