In vivo biomechanical stability of osseointegrating mesoporous TiO2 implants |
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| Authors: | Johan Karlsson Ryo Jimbo Hoda M. Fathali Humberto Osvaldo Schwartz-Filho Mariko Hayashi Mats Halvarsson Ann Wennerberg Martin Andersson |
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| Affiliation: | 1. School of Dentistry, China Medical University, Taichung 404, Taiwan;2. Department of Mechanical and Computer-Aided Engineering, National Formosa University, Yunlin 632, Taiwan;3. Department of Materials Science and Engineering, Mingdao University, Changhua 52345, Taiwan;4. School of Medicine, China Medical University, Taichung 404, Taiwan;5. Department of Dental Hygiene, China Medical University, Taichung, 404 Taiwan;1. Department of Orthopedics, The First Affiliated Hospital of Kunming Medical University, Kunming 650032, China;2. School of Materials Science and Engineering, Kunming University of Science and Technology, Kunming 650093, China;3. Department of Mechanical & Industrial Engineering, Northeastern University, Boston, Massachusetts 02115, United States;4. Department of Thoracic Surgery, The Third Affiliated Hospital of Kunming Medical University, Tumor Hospital of Yunnan Province, Kunming 650118, China;1. Department of Biomedical Engineering, Research Center for Nano-biomaterials & Regenerative Medicine, College of Biomedical Engineering, Taiyuan University of Technology, Taiyuan 030024, PR China;2. Shanxi Key Laboratory of Material Strength & Structural Impact, Institute of Biomedical Engineering, Taiyuan University of Technology, Taiyuan 030024, PR China;3. Division of Engineering in Medicine, Department of Medicine, Brigham and Women''s Hospital, Harvard Medical School, Cambridge, MA 02139, USA |
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| Abstract: | Mesoporous materials are of high interest as implant coatings to receive an enhanced osseointegration. In this study, titanium implants coated with mesoporous TiO2 thin films have been evaluated both in vitro and in vivo. Material characterization showed that, with partly crystalline TiO2 (anatase), long-range-ordered hydrophilic mesoporous thin films with a pore size of 6 nm were obtained. Evaluation of the mechanical resistance showed that the films were robust enough to withstand the standard implantation procedure. In vitro apatite formation was studied using simulated body fluids, showing that the pores are accessible for ions and that formation of apatite was increased due to the presence of the mesopores. An in vivo study using a rabbit model was executed in which the removal torque and histomorphometry were evaluated. The results show that the biomechanical stability of the TiO2 coating was unaffected by the presence of mesopores and that osseointegration was achieved without any signs of inflammation. |
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