The Association of eNOS G894T Polymorphism with Metabolic Syndrome and Erectile Dysfunction |
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| Authors: | Yung‐Chin Lee Shu‐Pin Huang Chia‐Chu Liu Yi‐Hsin Yang Hsin‐Chih Yeh Wei‐Ming Li Wen‐Jeng Wu Chii‐Jye Wang Yung‐Shun Juan Chun‐Nung Huang Tzyh‐Chyuan Hour Chu‐Fen Chang Chun‐Hsiung Huang |
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| Affiliation: | 2. Department of Urology, Faculty of Medicine, College of Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan;3. Graduate Institute of Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan;4. Pingtung Hospital, Department of Health, Executive Yuan, Pingtung, Taiwan;5. School of Pharmacy, Kaohsiung Medical University, Kaohsiung, Taiwan;11. Department of Urology, Kaohsiung Municipal Ta‐Tung Hospital, Kaohsiung, Taiwan;12. Department of Urology, Kaohsiung Municipal Hsiao‐Kang Hospital, Kaohsiung, Taiwan;8. Institute of Biochemistry, Kaohsiung Medical University, Kaohsiung, Taiwan;9. Institute of Biomedical Engineering, National Taiwan University, Taipei, Taiwan;2. Campus Biomedico Department of Obstetrics and Gynecology, University of Rome Via Longoni, Rome, Italy;2. Department of Psychiatry and Neurobehavioral Sciences, University of Virginia, Charlottesville, VA, USA;3. San Diego Sexual Medicine, Alvarado Hospital, San Diego, CA, USA;4. Sheppard Pratt Hospital, Baltimore, MD, USA;2. Department of Obstetrics and Gynecology, Alexandria University, Alexandria, Egypt;3. Department of Urology, S. Orsola Hospital, University of Bologna, Bologna, Italy;2. Department of Psychology, University of Michigan, Ann Arbor, MI, USA;3. Department of Psychology, California State University, Long Beach, Long Beach, CA, USA;4. Department of Obstetrics, Gynecology and Reproductive Sciences, Yale University School of Medicine, New Haven, CT, USA;2. Division of Medical Pharmacology, Leiden/Amsterdam Center for Drug Research, Leiden University Medical Centre, Leiden, The Netherlands;3. Department of Psychology, University of Michigan, Ann Arbor, MI, USA;4. Department of CNS Diseases, Boehringer Ingelheim, Biberach, Germany;5. Department of Obstetrics and Gynecology, University of Wisconsin‐Madison, Madison, WI, USA;2. Department of Obstetrics and Gynecology, Universidade Federal do Ceará, Fortaleza, Ceará, Brazil |
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| Abstract: | ![]()
IntroductionAccumulated evidences have outlined the potential relation between insulin resistance and endothelial dysfunction. The impaired ability of endothelium to synthesize or release nitric oxide may provide a common pathophysiological mechanism in the development of metabolic syndrome (MtS) and erectile dysfunction (ED).AimThe aim of this article was to investigate the genetic susceptibility of endothelial nitric oxide synthase (eNOS) G894T polymorphism underlying the development of both disorders.MethodsA total of 590 subjects with a mean (standard deviation) age of 55.3 years (4.1) were enrolled during a free health screening. Complete clinical data and questionnaires were taken for all subjects. Multivariate logistic regression analysis was used to determine the independent predictors of MtS and ED. The eNOS G894T polymorphism was determined using a polymerase chain reaction‐restriction fragment length polymorphism method.Main Outcome MeasuresThe definition of MtS was according to the modified criteria developed by the Bureau of Health Promotion in Taiwan. Patients with ED were defined as those having a five‐item International Index of Erectile Function (IIEF‐5) <21.ResultsOur results showed that the eNOS 894T allele carriers had significantly higher prevalence of MtS and ED (odds ratio [OR] = 1.64, 95% confidence interval [CI] = 1.05～2.56, P = 0.02 and OR = 1.76, 95% CI = 1.11～2.80, P = 0.01, respectively) after adjustment for each other and age. Also the T allele carriers had significantly lower IIEF‐5 score and more MtS components than G allele carriers (P < 0.01 and P < 0.01, respectively), which were significantly associated with an increment of the T allele number (P < 0.05).ConclusionsThe eNOS 894T allele carriers are at greater risk for both MtS and ED, suggesting that eNOS G894T gene polymorphism might play an implication as a common genetic susceptibility factor to develop both disorders. Lee Y‐C, Huang S‐P, Liu C‐C, Yang Y‐H, Yeh H‐C, Li W‐M, Wu W‐J, Wang C‐J, Juan Y‐S, Huang C‐N, Hour T‐C, Chang C‐F, and Huang C‐H. The Association of eNOS G894T polymorphism with metabolic syndrome and erectile dysfunction. J Sex Med 2012;9:837–843. |
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