| 促性腺激素释放激素类似物在儿童中枢性性早熟中的应用 |
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| 作者姓名： | 董关萍 傅君芬 |
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| 作者单位： | 国家儿童健康与疾病临床医学研究中心 |
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| 摘 要： | 促性腺激素释放激素(GnRH)依赖性性早熟/中枢性性早熟(GDPP/CPP)是儿科内分泌系统的常见病之一,促性腺激素释放激素类似物(GnRHa)是国际上治疗CPP的主要药物,其通过抑制下丘脑-垂体-性腺轴的活动和性激素分泌,减缓CPP患儿骨龄进展、改善成年身高。在临床实践中,仍需要不断探索GnRHa治疗的获益人群,探讨GnRHa的最佳治疗方案,不断完善GnRHa长期疗效和安全性证据。
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| 关 键 词： | 中枢性性早熟 促性腺激素释放激素类似物 指南 共识 诊断 治疗 儿童 |
Application of gonadotropin-releasing hormone analogues in children with central precocious puberty |
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| Authors: | Dong Guanping Fu Junfen |
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| Institution: | (Department of Endocrinologyy the Children's Hospital of Zhejiang University School of Medicine,National Clinical Research Center for Child Health,National Children's Regional Medical Center,Hangzhou 310052,China) |
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| Abstract: | Gonadotropin-releasing hormone(GnRH)dependent precocious puberty/central precocious puberty(GDPP/CPP)is one of the common diseases of the pediatric endocrine system.CPP is mainly treated with gonadotropin-releasing hormone analogues(GnRHa)internationally.They slow the progression of bone age and improve adult height in children with CPP by inhibiting the activity of the hypothalamic-pituitary-gonadal axis and the secretion of sex hormones.In clinical practice,the populations who benefit from GnRHa treatment and the best GnRHa treatment plan still need to be investigated,and the long-term efficacy and safety evidence of GnRHa should be further improved. |
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| Keywords: | Central precocious puberty Gonadotropin-releasing hormone analogues Guideline Consensus Diagnosis Treatment Child |
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