| 紫外线致皮肤光老化及光癌变机制的研究进展 |
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| 引用本文： | 佘金铭,车静,陈聪颖,卢丽艳,赵洋,余瑞新,崔蕾.紫外线致皮肤光老化及光癌变机制的研究进展[J].中华整形外科杂志,2021(2). |
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| 作者姓名： | 佘金铭 车静 陈聪颖 卢丽艳 赵洋 余瑞新 崔蕾 |
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| 作者单位： | 三峡大学第一临床医学院宜昌市中心人民医院医疗美容科 |
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| 摘 要： | 日光的累计照射可加速皮肤老化与癌变,使皮肤的生物学及临床反应发生改变,包括急性损伤(日晒伤)和慢性损伤(光老化、光癌变或色素沉着等)。文章概述了近年来紫外线对皮肤光老化及光癌变影响的研究进展,揭示光老化和光致癌机制是通过紫外线照射产生活性氧和DNA损伤,以及由此引起的细胞损伤、炎症、免疫抑制、细胞外基质重塑及血管生成改变所致,为临床防治光老化和光癌变提供帮助。
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| 关 键 词： | 皮肤衰老 紫外线 细胞外基质 活性氧 |
Advances in research on ultraviolet-induced skin photoaging and photocarcinogenesis |
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| She Jinming,Che Jing,Chen Congying,Lu Liyan,Zhao Yang,Yu Ruixin,Cui Lei.Advances in research on ultraviolet-induced skin photoaging and photocarcinogenesis[J].Chinese Journal of Plastic Surgery,2021(2). |
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| Authors: | She Jinming Che Jing Chen Congying Lu Liyan Zhao Yang Yu Ruixin Cui Lei |
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| Institution: | (Department of Medical Cosmetology,Yichang Central Peoples’s Hospital,the First College of Clinical Medical Science,China Three Gorges University,Yichang 443003,China) |
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| Abstract: | The cumulative exposure of sunlight can accelerate skin aging and canceration.It changes the biological and clinical reactions of the skin,including acute damage(sunburn)and chronic damage(photoaging,photocarcinogenesis,or pigmentation,etc.).This article summarizes the research progress in the effects of ultraviolet rays on skin photoaging and photocarcinogenesis in recent years.The mechanism of photoaging and photocarcinogenesis is the generation of ROS and DNA damage through ultraviolet irradiation,resulting cell damage,inflammation,immunosuppression,extracellular matrix remodeling and changes of angiogenesis.It provides help for the clinical prevention and treatment of photoaging and photocarcinogenesis. |
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| Keywords: | Skinaging Ultraviolet rays Extracellular matrix Reactive oxygen species |
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