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Mediastinal Malignant Melanoma Markedly Shrinking in Response to Nivolumab
Authors:Hiroyuki Sakaguchi  Azusa Tanimoto  Shigeki Sato  Naohiro Yanagimura  Chiaki Suzuki  Yohei Takumi  Akihiro Nishiyama  Kaname Yamashita  Shinji Takeuchi  Koshiro Ohtsubo  Seiji Yano
Affiliation:1.Division of Medical Oncology, Cancer Research Institute, Kanazawa University, Japan; 2.WPI-Nano Life Science Institute (WPI-Nano LSI), Kanazawa University, Japan
Abstract:
Primary malignant melanoma (MM) of the mediastinum is rare, and there is a lack of consensus regarding the preferred treatment because non-cutaneous MM demonstrates an inferior response to systemic therapy. Herein, we describe the case of a 73-year-old man with MM of the anterior mediastinum with multiple liver metastases. Even though the size of lesions increased rapidly following diagnosis, nivolumab monotherapy caused remarkable tumor shrinkage. This is the first report of mediastinal MM showing a significant response to nivolumab. We, therefore, suggest that immunotherapy may be one of the treatment options for primary mediastinal MM.
Keywords:mediastinal tumor   malignant melanoma   nivolumab   immunotherapy
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