| 米氮平与帕罗西汀联用治疗难治性抑郁症的对照研究 |
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| 引用本文： | 王金明,马洪涛. 米氮平与帕罗西汀联用治疗难治性抑郁症的对照研究[J]. 中国民康医学, 2011, 23(5): 550-552. DOI: 10.3969/j.issn.1672-0369.2011.05.011 |
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| 作者姓名： | 王金明 马洪涛 |
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| 作者单位： | 1. 烟台市心理康复医院,山东,莱阳,265200
2. 山东省莱芜市荣军医院 |
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| 摘 要： | 目的:探讨米氮平与帕罗西汀合用治疗难治性抑郁症患者的疗效与不良反应。方法:将84例难治性抑郁症患者随机分为两组,治疗组给予米氮平与帕罗西汀联用,以帕罗西汀单用治疗作为对照组。于入组前及治疗后第2、4、6周进行汉密尔顿抑郁量表(HAMD),社会功能缺陷筛选量表(SDSS),不良反应量表(TESS)评定。结果:6周时治疗组显进率为72.7%,总有效率为86.4%;对照组分别为50.0%、75.0%。研究组显效率与对照组比较差异有显著性(P<0.05)。研究组HAMA、SDSS评分在6周末减分率与对照组比较均有显著性差异(P<0.05)。TESS评定示不良反应相当(P>0.05)。结论:两药联用治疗难治性抑郁症疗效好,安全性高,且能显著改善患者的社会功能。
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| 关 键 词： | 米氮平 帕罗西汀 联用 难治性抑郁症 |
Follow-up comparison study of Mirtazapine and Paroxetine union apply for treatment-resistant depression |
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| WANG Jin-ming,MA Hong-tao. Follow-up comparison study of Mirtazapine and Paroxetine union apply for treatment-resistant depression[J]. medical journal of chinese peoples health, 2011, 23(5): 550-552. DOI: 10.3969/j.issn.1672-0369.2011.05.011 |
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| Authors: | WANG Jin-ming MA Hong-tao |
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| Affiliation: | WANG Jin-ming,MA Hong-tao(The psycho-rehabitation hospital of Yantai,Shandong.265200,China) |
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| Abstract: | Objective:To explore efficacy and adverse effect of Mirtazapine and Paroxetine union apply for treatment-resistant depression(TRD).Methods:84 TRD patients were randomly selected assigned to study group and control group.The study group were treated with Mirtazapine and Paroxetine,control group were treated with Paroxetine separately.The period study was 6 weeks.The efficacy and side effects were rated with PANSS,SDSS and TESS before treatment and in the end of 2,4,6 weeks.Results: At the end of 6th week,in ... |
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| Keywords: | Treatment-resistant depression Mirtazapine Paroxetine Union apply |
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