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| 丙戊酸镁缓释片治疗躁狂发作69例的疗效及安全性 | |
| 引用本文： | 王秀梅,李刚,穆小梅,魏长礼,李忠义. 丙戊酸镁缓释片治疗躁狂发作69例的疗效及安全性[J]. 中国民康医学, 2011, 23(5): 528-529,532. DOI: 10.3969/j.issn.1672-0369.2011.05.002 |
| 作者姓名： | 王秀梅 李刚 穆小梅 魏长礼 李忠义 |
| 作者单位： | 甘肃省天水市第三人民医院,甘肃,天水,741000 |
| 摘 要： | 目的:为了探讨丙戊酸镁缓释片治疗躁狂发作的疗效及安全性。方法:收集各类躁狂发作、双相躁狂发作、快速循环发作患者139例,分为丙戊酸镁组(研究组)和碳酸锂组(对照组),研究组69例,对照组70例,疗程6周。在治疗前、1、2、4、6周末采用倍克-拉范森躁狂量表(BRMS)、治疗中出现的症状量表(TESS)评定不良反应。结果:治疗6周两组BRMS量表减分值相仿(P>0.05),研究组在治疗1周末,BRMS平均因子分比治疗前有所下降(P<0.05),而对照组在治疗2周末,BRMS平均因子分比治疗前有所下降(P<0.05)。研究组有效率92.6%(63/68),显效率66.2%(45/68);对照组有效率88.1%(59/67),显效率62.7%(42/67)。两组间疗效无显著性差异(P>0.05)。对照组不良反应出现的频率高于研究组,但无显著性差异(P>0.05)。研究组脱落1例,对照组脱落3例。结论:丙戊酸镁缓释片治疗躁狂发作,起效快,疗效好,安全性高。 |
| 关 键 词： | 躁狂发作 丙戊酸镁缓释片 碳酸锂 |
Effect and safety combination therapy of magnesium valproate sustained release tablets and lithium carbonas on manic episode |
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| WANG Xiu-mei,LI Gang,MU-xiaomei,et al. Effect and safety combination therapy of magnesium valproate sustained release tablets and lithium carbonas on manic episode[J]. medical journal of chinese peoples health, 2011, 23(5): 528-529,532. DOI: 10.3969/j.issn.1672-0369.2011.05.002 | |
| Authors: | WANG Xiu-mei LI Gang MU-xiaomei et al |
| Affiliation: | WANG Xiu-mei,LI Gang,MU-xiaomei,et al(Tianshui mental hospital,Gansu 741000,China) |
| Abstract: | Objective:To detect the efficacy safety of magnesium valproate sustained release tablets and lithium carbonate in the treatment of manic episode.Methods:139 patients with manic episode were randomly administered with magnesium valproates(n=69) and lithium carbonas(n=70),The therapeutics effects and side effects were assessed with Beth-Rafaelsen Measuring Scale(BRMS),Treatment Emergent symptom Scale(TESS) 1,2,4 and 6 weeks later.Results: The two groups showed same in efficacy.No significant difference was fo... |
| Keywords: | Manic episode Magnesium valproate sustained release tablets Lithium carbonate |
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