利肝克纤冲剂抗肝纤维化的临床研究

目的：观察中药利肝克纤冲剂在抗肝纤维化方面的疗效。方法：选取90例肝纤维化患者随机分为两组，治疗组60例，对照组30例，治疗6个月。观察治疗前后两组患者的症状、体征、肝功能、肝纤维化指标及B超影像学的变化，评价中药利肝克纤冲剂抗肝纤维化的疗效。结果：治疗组总有效率为86．67％，对照组总有效率为43．33％，两组比较，差异具有显著性意义（P〈0．01）。结论：利肝克纤冲剂可明显改善肝纤维化患者的症状、体征、肝功能、血清肝纤维化4项指标（HA、LN、PCⅢ及Ⅳ-c）及B超影像学表现，具有明显抗肝纤维化疗效。

Therapeutic effect of Ligan Kexian granule on hepatic fibrosis

To observe the curative effect caused by Ligan Kexian granule in terms of anti-hepatofibrosis. Methods： Ninety patients were divided into treatment group （60 cases） and contrast group （30 cases） at random. After 6 months treatment, to observe the change of clinical symptoms, signs, hepatic function, hepatofibrosis index and B-ultrasonography. To estimate the curative effect caused by Ligan Kexian granule in terms of anti-hepatofibrosis. Results： The results showed the total effective rate was 86. 67% in the treatment group, and there was significant difference with contrast group （ P 〈 0. 01 ）. Conclusion： Ligan Kexian granule can evidently improve the clinical symptoms, signs, hepatic function, hepatofibro- sis index （HA, LN, PC Ⅲ and IV-C） and B-ultrasonography of the patients with hepatofibrosis. Ligan Kexian graunle has evident curative effect in terms of anti-hepatofibrosis.