Enzymic biomedical research and new drug development

The proceedings of a symposium on current trends in enzyme-guided biomedical research and its relation to potential new drug discovery are reviewed. Topics under discussion include current concepts in enzyme inhibition, the mechanism and inhibition of phopholipase A₂, 5-lipoxygenase and inflammation, the protease/antiprotease hypothesis of emphysema, carbonic anhydrase and glaucoma, GTP-binding proteins and adenylate cyclase, and the calpain hypothesis of memory storage.