新疆少数民族亲属活体肾移植供体安全性随访研究(附55例报告)

目的探讨新疆维吾尔族自治区(新疆)少数民族亲属活体肾移植中供肾切除术对供体安全性的影响。方法对55例活体肾移植供体进行随访,复查肾功能、24 h尿蛋白定量等常规检查,并与供者进行沟通,了解其心理状况和生活质量。对供者术前、术后7 d、术后6个月、术后1年、术后3年、术后5年的血清肌酐(Scr)、内生肌酐清除率(Ccr)和血压进行比较。结果 55例供体中,术后出现气胸1例,切口延迟愈合2例,切口血肿4例,经处理后均恢复正常,平均住院时间11 d。随访6～86个月,其中2例供者术后6个月内尿红细胞3～5/HP,2例出现一过性蛋白尿。术后供体各时段的肾功能(Scr和Ccr)和血压(收缩压与舒张压)均在正常范围内,术后7 d、6个月、1年、3年、5年的Scr、Ccr、血压与术前相应指标比较,差异均无统计学意义(均为P>0.05)。在随访期间所有供体家庭生活和日常工作未受到影响。结论新疆少数民族亲属活体供肾是安全可行的,供者在捐肾后肾功能未见减退,且生活质量较好。

A follow-up study on donor safety in living-related donor renal transplantation in Xinjiang minority

Objective To investigate the influence of kidney excision on donor safety in living-related donor renal transplantation in Xinjiang minority.Methods Fifty-five living donors of renal transplantation were followed up in this study.The renal function and 24 h urinary protein quantitation were measured regularly.Full communication was made to know the psychological condition and quality of life in all donors.The serum creatinine(Scr),endogenous creatinine clearance rate(Ccr) and blood pressure of donors were compared at different time points,including pre-operation,7 days,6 months,1 year,3 years and 5 years after operation.Results In 55 donors,1 case developed pneumothorax.Two cases suffered from delayed healing of incision and 4 cases had incision hematoma.All of them recovered to normal after treatment.The average time of hospitalization was 11 days and the patients were followed up from 6 to 86 months.Red blood cells in urine(3-5/HP) were found in 2 donors within 6 months after operation.And two cases developed transient proteinuria.The renal function(Scr and Ccr) and blood pressure(systolic pressure and diastolic pressure) of donors were in normal range at all times after operation.There was no significant difference in Scr,Ccr and blood pressure between post-operation and pre-operation(all in P>0.05).During the follow-up period,the routine life and work was not influenced in all donors.Conclusions It is safe and feasible of performing living-related donor renal transplantation in Xinjiang minority.The donors have good quality of life with no renal injury after kidney donation.