叶下珠复方抗小鼠肝纤维化作用的实验研究

目的 探讨叶下珠复方（PUC）对小鼠实验性肝纤维化的影响。方法 经小鼠皮下多次注射CCL4，促成小鼠肝纤维化，同时给予大，中、小剂量的PUC，并以秋水仙碱做阳性对照药。给药6周后检测小鼠血清中的谷丙转氨酶（ALT），谷草转氨酶（AST），超氧化物歧化酶（SOD），丙二醛（MDA），总蛋白（TP），白蛋白（ALB）及肝组织中的羟辅氨酸（Hyp)含量，并观察小鼠肝组织病理改变。结果 PUC各剂量组均可升高血清中SOD含量及降低其它指标的含量。并且高剂量PUC对升高ＳＯＤ和降低ＡＬＴ，AST，MDA，Hyp的效果优于秋水仙碱，病理观察表明PUC可减轻CCL4所致的小鼠肝组织纤维化程度。结论 PUC有抗CCL4所致的肝纤维化作用。

Inhibition of experimental hepatofibrosis in mice by Phyllanthus Urinaria Compound (PUC)

Objective To study the inhibition of experimental hepatofibrosis in mice by PUC Methods The experimental hepatofibrosis was produced by CCL 4 in mice. At the same time, PUC was given to prevent from heptofibrosis in other groups. Colchicines was used as a positive control medicine. Six weeks later, the experimental mice were taken blood for the examination of ALT, AST, Superoxide dismutase (SOD), malondialdehyde (MDA), total protein (TP), albumin (ALB) and were taken liver specimen for the observation of pathology Results PUC can increase the level of SOD but decrease the contents of ALT, AST, MDA, HyP, especially high dose of PUC ( 60g of PUC per Kg mice body weight ) has a better curative effect than colchicines. Pathological examination indicates PUC can protect mice from hepatofibrosis Conclusions PUC is capable of inhibiting hepatofibrosis