柴胡疏肝散在肝脏疾病中的应用研究进展

柴胡疏肝散出自《景岳全书》,由柴胡、川芎、陈皮、芍药、香附、炙甘草、炒枳壳7味中药组成,其主要功效为疏肝解郁、理气止痛,常用于治疗肝郁气滞引起的两胁肋部疼痛,胸闷善太息,情绪急躁易怒,反酸嗳气,脘腹胀满等。现代药理学研究发现,其组方主要包含皂苷类、黄酮类、酚酸类、萜类四种成分,具有抗炎、镇痛、护肝、抗肿瘤等多种药理作用,应用于各种肝脏疾病中可以有效改善患者症状、体征,改善肝功能、肝纤维化、血脂指标,提高患者生存质量。现从柴胡疏肝散近年来在肝纤维化、肝癌、肝硬化、脂肪肝、慢性胆囊炎等肝脏疾病中的相关应用,对柴胡疏肝散的最新研究动态进行综述,为临床应用柴胡疏肝散治疗肝脏疾病提供依据。

Application of Chihu Shugan powder in liver diseases

The original formula of Chaihu Shugan powder is composed of 7 main traditional Chinese medicines including cymbidium perfoliatum,ligusticum chuanxiong,tangerine peel,peony,rhizoma cyperi,prepared licorice and fried fructus aurantii.Its main functions are to soothe the liver and relieve depression,regulate Qi and relieve pain.It is often used for the treatment of rib pain,chest tightness and excessive breath,emotional depression and irritability,belching,abdominal distension and fullness.Modern pharmacology study found that the formula contains saponins,flavonoids,phenolic acids,terpenoids,saponins,flavonoids,phenolic acids and other ingredients,has anti-inflammatory and analgesic,protect liver,fall hematic fat,antioxidation,antivirus,antitumor,pharmacological effects,such as in liver disease can effectively improve the patient's symptoms,signs,reduce the liver function and liver fibrosis index,blood lipid index,improve patients' quality of life.This paper reviews the latest research trends of Chaihu Shugan powder in recent years from the relevant application of Chaihu Shugan powder in liver fibrosis,liver cancer,cirrhosis,fatty liver,chronic cholecystitis and other liver diseases,so as to provide more powerful evidence for the effective application of Chaihu Shugan powder in the treatment of liver diseases.