能谱CT基物质分离技术定量评估乙肝肝纤维化分期的价值

目的:探讨能谱CT基物质分离技术在定量评估乙肝肝纤维化分期中的应用价值。方法:选取33例乙肝肝纤维化患者为试验组，18名健康体检者为对照组，采用能谱CT基物质分离技术分别在碘（水）基物质图上测量每名受检者肝实质及同层腹主动脉的碘（水）浓度，并计算肝脏标准化碘浓度（NIC）。以肝穿刺活检病理结果为金标准，采用单因素方差分析及最小显著性差异法比较不同分期乙肝肝纤维化间NIC的差异，Spearman相关分析用于评估乙肝肝纤维化分期与NIC之间的相关性，同时绘制ROC曲线分析NIC评估不同分期乙肝肝纤维化的价值。结果:不同分期乙肝肝纤维化间NIC存在差异（F=36.889, P<0.001）。NIC与不同分期乙肝肝纤维化间呈高度负相关性（r=-0.847, P<0.001）。NIC鉴别S0<和≥s1、s1><和≥s2、 />

Application of basis material decomposition technique with spectral CT in quantitatively evaluating the stage of hepatitis B liver fibrosis

Abstract: Objective To explore the application value of basis material decomposition technique with spectral CT in the quantitative assessment of hepatitis B liver fibrosis stage. Methods Thirty-three patients with hepatitis B liver fibrosis were enrolled as experimental group, and 18 healthy subjects as control group. The iodine (water) concentration of liver parenchyma and abdominal aorta in the same layer of each patient was measured on the iodine (water) basis material map using basis material decomposition technique with spectral CT, and then the normalized iodine concentration (NIC) of the liver was calculated. Taking the pathological results of liver biopsy as the gold standard, one-way analysis of variance and least significant difference were used to compare the differences in NIC between different stages of hepatitis B liver fibrosis. Spearman correlation analysis was used to evaluate the correlation between hepatitis B liver fibrosis stage and NIC. Meanwhile, ROC curve was drawn to analyze the value of NIC in evaluating different stages of hepatitis B liver fibrosis. Results There were differences in NIC among different stages of hepatitis B liver fibrosis (F=36.889, P<0.001), and NIC had a negative correlation with different stages of hepatitis B liver fibrosis (r=-0.847, P<0.001). The AUC, sensitivity, specificity, positive predictive value, negative predictive value and accuracy of NIC in differentiating between S0< and ≥S1, S1< and ≥S2,