Maternal serum ratio of ghrelin to obestatin decreased in preeclampsia |
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| Affiliation: | 1. Department of Obstetrics & Gynecology, Affiliated Hospital, Logistical College of Chinese People’s Armed Police Forces, Tianjin 300162, PR China;2. Maternity & Children Hospital of Northwest District, Shaanxi, Xi’an 710003, PR China;3. Department of Obstetrics & Gynecology, Xijing Hospital, Fourth Military Medical University, Shaanxi, Xi’an 710033, PR China;1. Department of Maternity Services, Royal Women’s Hospital, Cnr Flemington Rd and Grattan St, Parkville 3053, Australia;2. Department of Statistical Risk Management, KPMG, 147 Collins St, Melbourne 3000, Australia;3. Department of Obstetrics and Gynecology, University of Melbourne, Australia;1. ORS PACA, Southeastern Health Regional Observatory, Marseille, France;2. Aix Marseille Univ, INSERM, IRD, SESSTIM, Economics and Social Sciences Applied to Health & Analysis of Medical Information, Marseille, France;3. Aix Marseille University, Department of General Practice, Marseille, France;4. Agence régionale de santé PACA (Regional Health Agency), Department of Studies and Observation, Marseille, France;5. Direction Régionale du Service Médical de l’Assurance Maladie Provence-Alpes-Côte d’Azur et Corse (CNAMTS), France;1. College of Food Science and Technology, Henan University of Technology, Zhengzhou 450001, China;2. National Engineering Laboratory for Wheat and Corn Further Processing, Zhengzhou 450001, China;1. Westmead Hospital, Sydney, NSW, Australia;2. Sydney Medical School, University of Sydney, Australia;1. National Resource Center for Women’s Health, Oslo University Hospital Rikshospitalet, Oslo, Norway;2. Department of Cardiology, Oslo University Hospital Rikshospitalet, Oslo, Norway;3. Department of Anaesthesiology, Oslo University Hospital Rikshospitalet, Oslo, Norway;4. Institute for Surgical Research, Oslo University Hospital Rikshospitalet, Oslo, Norway;5. Section of Specialized Endocrinology, Oslo University Hospital Rikshospitalet, Oslo, Norway;6. Department of Obstetrics, Oslo University Hospital Rikshospitalet, Oslo, Norway;7. Research Institute for Internal Medicine, Oslo University Hospital Rikshospitalet, Oslo, Norway;8. Section of Clinical Immunology and Infectious Diseases, Oslo University Hospital Rikshospitalet, Oslo, Norway;9. Faculty of Medicine, University of Oslo, Oslo, Norway;10. K.G. Jebsen Inflammatory Research Center, University of Oslo, Oslo, Norway;11. K.G. Jebsen Cardiac Research Center and Center for Heart Failure Research, University of Oslo, Oslo, Norway;1. University of Vermont, Department of Obstetrics, Gynecology and Reproductive Sciences, Burlington, VT 05405, United States;2. University of Vermont, Department of Medical Biostatistics, Burlington, VT 05405, United States;3. University of Vermont, Department of Pediatrics, Burlington, VT 05405, United States;4. Vermont Oxford Network, Burlington, VT 05401, United States |
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| Abstract: | ![]()
ObjectiveGhrelin, an endogenous for the growth hormone secretagogue receptor, has been shown to participate in blood pressure regulation. Obestatin, encoded by the same gene as ghrelin, is described as a physiological opponent of ghrelin. We hypothesized that ghrelin/obestatin imbalance played a role in the pathogenesis. This study was designed to determine the alterations of ghrelin and obestatin concentrations and ghrelin/obestatin ratio in maternal serum in preeclampsia.MethodThis retrospective case–control study included 31 preeclampsia and 31 gestational week-matched normal pregnancies. Ghrelin and obestatin concentrations in maternal serum were determined by radioimmunoassay, and the ghrelin/obestatin ratio was calculated.ResultsThe ghrelin concentration and ghrelin/obestatin ratio in maternal serum were significantly lower in preeclampsia than in normal pregnancies (214.34 ± 14.27 pg/mL vs 251.49 ± 16.15 pg/mL, P = 0.041, 1.07 ± 0.09 vs 0.82 ± 0.08, P = 0.023). The obestatin concentration in maternal serum was significantly higher in preeclampsia than in normal pregnancies (276.35 ± 15.38 pg/mL vs 223.53 ± 18.61 pg/mL, P = 0.019). The systolic blood pressure in preeclampsia was negatively correlated with ghrelin concentration and ghrelin/obestatin ratio (r = −0.549, P = 0.003; r = −0.491, P = 0.004) and was positively correlated with obestatin concentrations in preeclampsia (r = 0.388, P = 0.013).ConclusionsThe findings of this study suggested disturbance of ghrelin and obestatin in maternal serum in preeclampsia, and ghrelin/obestatin imbalance might play a role in the pathogenesis of preeclampsia. |
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| Keywords: | Ghrelin Obestatin Pregnant complication Preeclampsia Blood pressure |
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