非肌层浸润性膀胱癌基底注水后经尿道逆行膀胱肿瘤整块剜除术疗效分析

目的 评估非肌层浸润性膀胱癌（NMIBC）基底注水后经尿道逆行膀胱肿瘤整块剜除术（EEBT）的安全性及有效性。方法 收集60例NMIBC患者的临床资料，根据手术方案分为2组，其中行膀胱癌基底注水后经尿道逆行EEBT患者30例（EEBT组），常规行经尿道膀胱肿瘤切除术（TURBT）患者30例（TURBT组）。比较2组的基线资料、围术期指标、术后肿瘤病理分级和分期及病理科医师对标本的满意度；对患者进行随访，比较2组的肿瘤复发率。结果 2组患者的性别构成、年龄、肿瘤大小、肿瘤位置、单发或多发肿瘤比例、术前合并其他疾病等比较差异均无统计学意义（P均> 0.05）。EEBT组和TURBT组在膀胱穿孔率、术后肿瘤病理分级、病理T分期比较差异亦均无统计学意义（P均> 0.05）。与TURBT组相比，EEBT组的手术时间长，但是患者术中失血少、闭孔神经反射发生率低，术后留置尿管时间及住院时间均较短，病理科医师对标本的满意度较高，术后1年内肿瘤复发率较低（P均<0.05）。结论 与TURBT比较，采用基底注水后经尿道逆行EEBT治疗NMIBC，具有出血少、恢复快、肿瘤标本完整、1年内肿...

Clinical efficacy of transurethral retrograde en-bloc excavation of bladder tumor after basal injection with sterile water on non-muscular invasive bladder cancer

Objective To evaluate the safety and efficacy of transurethral retrograde en-bloc excavation of bladder tumor （EEBT） after basal injection with sterile water for non-muscular invasive bladder cancer （NMIBC）. Methods Clinical data of 60 patients with NMIBC were analyzed retrospectively. All patients were divided into two groups according to the surgical procedure. In the EEBT group, 30 patients received transurethral EEBT after basal injection with sterile water, and 30 patients underwent conventional transurethral resection of bladder tumor （TURBT） in the TURBT group. The baseline data, perioperative parameters, postoperative tumor pathological stage and the pathologists’ degree of satisfaction with the specimen were compared between two groups. All patients received follow-up. The tumor recurrence rate was statistically compared between two groups. Results There was no significant difference in gender, age, tumor size, tumor location, proportion of single and multiple tumors and preoperative complications between two groups （all P > 0.05）. No statistical significance was also observed in the bladder perforation rate, postoperative tumor pathological stage and pathological T stage between EEBT group and TURBT group（all P > 0.05）. Compared with the TURBT group, the operation time was longer, whereas intraoperative blood loss was less, the incidence of obturator reflex was lower, postoperative indwelling catheter time and the length of hospital stay were shorter, the pathologists’ degree of satisfaction with the specimen was higher, and the one-year tumor recurrence rate was lower in the EEBT group （all P < 0.05）. Conclusion Compared with TURBT, transurethral retrograde EEBT after basal injection with sterile water has multiple advantages of less intraoperative blood loss, faster postoperative recovery, intact tumor specimen and lower one-year tumor recurrence rate in the treatment of NMIBC.