术前炎症和营养预后指数在胃癌预后评估中的价值

【目的】探讨胃癌患者术前炎症和营养预后指数（PINI）水平与胃癌近期疗效的关系。【方法】选择2010年4～12月本科收治的胃癌患者36例，均于术前3d测定血清α1-酸性糖蛋白、C-反应蛋白、白蛋白和前白蛋白水平，并以此计算术前PINI值。术后随访2～6个月，分析术前PINI水平与患者病理分期、术后并发症、生活质量及复发转移的关系。【结果】术前PINI水平与病理TNM分期有关：Ⅳ期PINI水平明显高于Ⅰ、Ⅱ及Ⅲ期（P〈O．01）。术前PINI水平与患者术后并发症有关：发生并发症患者其PINI水平明显高于无并发症者（P〈0．05）。术前PINI水平与患者术后生存质量总体评估水平有关：生存质量“差”者，其PINI水平明显高于生存质量“好”及“一般”者（P〈0．05）。【结论】术前PINI可作为胃癌患者短期预后的评估指标之一。

Value of Preoperative Prognostic Inflammatory and Nutritional Prognosis Index in Prognostic Evaluation of Gastric Cancer

[Objective] To explore the relationship between preoperative prognostic inflammatory and nutritional index（PINI） and short-term efficacy of gastric cancer. [Methods] Thirty six patients with gastric cancer in our hospital from April 2010 to Dec. 2010 were chosen. Serum alpha-1-acid glycoprotein, C-reactive protein, albumin and prealbumin were examined on 3rd day before operation, and the value of preoperative PINI was calculated. All patients were followed up for 2-6 months after operation. The relationship between preoperative PINI and pathological stage, postoperative complications, quality of life, recurrence and metastasis were analyzed. [Results]Preoperative PIN＇I value was correlated with TNM stage. PINI value in patients with IV stage was significantly higher than that in patients with Ⅰ , Ⅱ and Ⅲ stage（ P 〈0.01）. Preoperative PINI value was correlated with postoperative complications. Preoperative PINI value in patients with postoperative complications was significantly higher than that of patients without complications（ P 〈0.05）. Preoperative PINI value was correlated with postoperative overall quality of life. Preoperative PINI value in patients with poor quality of life was significantly higher than that in patients with moderate and well quality of life（ P 〈0.05）. [Conclusion] Preoperative PINI value can be used as an index to assess the short-term prognosis of gastric cancer.