| 乳腺癌组织中COX-2与MMP-2的表达及其意义 |
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| 引用本文： | 王秀清,刘惠民,郭梅艳,沈香荣,王立,李晓璀,范杰,刘卫欣,席丰. 乳腺癌组织中COX-2与MMP-2的表达及其意义[J]. 重庆医学, 2011, 40(23): 2289-2290,2393. DOI: 10.3969/j.issn.1671-8348.2011.23.001 |
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| 作者姓名： | 王秀清 刘惠民 郭梅艳 沈香荣 王立 李晓璀 范杰 刘卫欣 席丰 |
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| 作者单位： | 河北工程大学附属医院病理科,河北邯郸,056002 |
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| 基金项目： | 邯郸市科技局重点资助项目 |
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| 摘 要： | 目的探讨环氧合酶-2(COX-2)、基质金属蛋白酶-2(MMP-2)在乳腺浸润性癌中的表达情况及它们之间的相互关系。方法采用免疫组化SP法检测100例乳腺癌及40例正常乳腺组织中COX-2、MMP-2的表达情况。结果 COX-2蛋白在正常乳腺组织及乳腺癌中的阳性表达率分别为7.5%(3/40)、83.0%(83/100),而且COX-2在淋巴结转移组中的阳性表达率[90.0%(54/60)]明显高于无淋巴结转移组(P<0.05)。MMP-2蛋白在正常乳腺组织及乳腺癌中的阳性表达率分别为0(0/40)、94.0%(94/100),而且MMP-2在淋巴结转移组中的阳性表达率[98.3%(59/60)]明显高于无淋巴结转移组[87.5%(35/40)](P<0.05)。COX-2和MMP-2表达呈正相关关系(r=0.334,P<0.05)。结论检测COX-2、MMP-2表达将有助于判断乳腺癌的转移潜能及预后。
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| 关 键 词： | 氧合酶类 基质金属蛋白酶2 乳腺肿瘤 |
The expression and correlation between Cox-2 and MMP-2 in breast carcinoma |
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| Wang Xiuqing,LIU Huimin,Guo Meiyan,Shen Xiangrong,Wang Li,Li Xiaocui,Fan Jie,Liu Weixin,Xi Feng. The expression and correlation between Cox-2 and MMP-2 in breast carcinoma[J]. Chongqing Medical Journal, 2011, 40(23): 2289-2290,2393. DOI: 10.3969/j.issn.1671-8348.2011.23.001 |
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| Authors: | Wang Xiuqing LIU Huimin Guo Meiyan Shen Xiangrong Wang Li Li Xiaocui Fan Jie Liu Weixin Xi Feng |
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| Affiliation: | Wang Xiuqing,LIU Huimin,Guo Meiyan,Shen Xiangrong,Wang Li,Li Xiaocui,Fan Jie,Liu Weixin,Xi Feng(Department of Pathology,the Hospital of Hebei Engineering University Medical College,Handan,Hebei 056002,China) |
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| Abstract: | Objective To detect the expression of Cox-2 and MMP-2 in invasive breast carcinoma,and explore their correlation.Methods The expression of Cox-2 and MMP-2 were studied in 100 cases of invasive breast carcinoma by SP immunohistochemistry.Results The positive expression of Cox-2 protein in normal breast tissue and breast carcinoma were7.5%(3/40)and 83.0%(83/100)respectively,and the positive rate of Cox-2 in the lymph node metastasis(54/60) was significantly higher than those without lymph node metastasis(P<0.... |
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| Keywords: | oxygenases matrix metalloproteinase 2 breast neoplasms |
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