慢性心力衰竭患者高敏C-反应蛋白及肌钙蛋白的浓度变化及其临床意义

目的讨论高敏C-反应蛋白(CRP)及肌钙蛋白(cTnI)浓度的测定对慢性心力衰竭患者(CHF)的临床意义。方法选择2010年6月至2011年10月于我科诊断为CHF并接受治疗的98例患者为实验组,并以60例健康患者为对照组,分别将对照与实验组治疗前后CRP、cTnI水平情况进行比较,并分析其临床意义。结果①治疗前实验组患者CRP、cTnI水平明显高于对照组,差异具有统计学意义(P<0.05);②治疗前各心力衰竭组患者随着心力衰竭水平的升高CRP、cTnI水平显著升高,差异具有统计学意义(P<0.05)。③治疗后实验组患者CRP、cTnI水平基本恢复至对照组水平,无统计学差异(P>0.05)。结论高敏C-反应蛋白(CRP)及肌钙蛋白(cTnI)浓度的变化可以判断心力衰竭患者心功能水平,并且可以通过CRP、cTnI水平判断治疗效果。

High-sensitivity C-reactive Protein and Troponin I Concentrations of Chronic Heart Failure Patients and its Clinical Significance

Objective To discuss the clinical significance of high-sensitivity C-reactive protein（CRP） and troponin（cTnI） concentrations determination in patients with chronic heart failure（CHF）.Methods 98 patients from June 2010 to October 2011 in our department and diagnosed with CHF treated for the experimental group,and regard 60 healthy persons as control group,respectively,compared CRP,cTnI levels in control and experimental groups before and after treatment,and analyzed its clinical significance.Results ①Before treatment,CRP,cTnI levels of experimental group patients were significantly higher,the difference was statistically significant（P0.05）;②Before treatment,CRP,cTnI levels were significantly increased with the increasing of heart failure levels,the difference was statistically significant（P0.05）.③After treatment,CRP,cTnI levels of the experimental group were recovered to control levels,no significant difference（P0.05）.Conclusion Can determine the level of cardiac function in patients with heart failure through High-sensitivity C-reactive protein（CRP） and troponin（cTnI） concentration changes,and determine the efficiency of treatment by CRP,cTnI level.