maspin和bax联合检测对乳腺癌复发的研究

目的：研究乳腺癌组织中mas pin和bax的表达,探讨二者预测乳腺癌复发的价值。方法：采用SP免疫组织化学方法检测30例复发乳腺癌、24例无复发乳腺癌及14例乳腺纤维腺瘤组织中maspin和bax的表达情况。结果：复发乳腺癌（23.3%,20.0%）和无复发乳腺癌组织（54.2%,45.8%）maspin、bax阳性表达率均较乳腺纤维腺瘤组织（85.7%,78.6%）低（P均〈0.05）,复发乳腺癌maspin和bax阳性表达明显低于无复发乳腺癌（P〈0.01）。复发乳腺癌组织maspin表达与组织学分级呈负相关（r=-0.481,P〈0.05）,与激素受体呈正相关（r=0.497,P〈0.05）;bax表达与组织学分级呈负相关（r=-0.522,P〈0.05）;maspin表达与bax表达呈正相关﹙r=0.454,P〈0.05﹚。结论：maspin、bax的异常表达可能在乳腺癌的发生、发展过程中起重要作用,联合检测能更好地判断乳腺癌的复发。

Study of combined determination of maspin and bax for predicting the prognosis of breast carcinoma

Objective: To study the expression of β-Cat and NF-κB in breast carcinoma tissues and their value in predicting the recurrence of breast carcinoma.Methods: SP immunochemical method was performed to detect the expression of β-Cat and NF-κB in 30 cases of recurrent breast carcinoma,24 cases of non-recurrent breast carcinoma and 14 cases of benign breast tissues.Results: The positive rates of maspin and bax were significantly decreased in recurrent breast carcinoma(23.3%,20.0%) and no recurrent breast carcinoma(54.2%,45.8%) as compared with benign breast tissues(85.7%,78.6%).The positive expression of maspin and bax were significantly decreased in recurrent breast carcinoma as compared with non-recurrent breast carcinoma(P<0.01).In recurrent breast carcinoma tissues,maspin expression had a negtive correlation with histologic grader(r=-0.481,P<0.05),but positive correlation to estrogen and progesterone receptor(r=0.497,P<0.05);bax expression had a negtive correlation with histologic grade(r=-0.522,P<0.05);maspin and bax expression had positive correlation(r=0.454,P<0.05).Conclusion: Maspin and bax may play an important role in the occurrence and progression of breast cancer,and suggests that their combined detection is valuable for better prediction of the prognosis of breast cancer.