| 毛细管气相色谱法测定克痢痧胶囊中丁香酚含量 |
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| 引用本文： | 卢智玲,刘华栋. 毛细管气相色谱法测定克痢痧胶囊中丁香酚含量[J]. 中国药业, 2012, 21(4): 32-33 |
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| 作者姓名： | 卢智玲 刘华栋 |
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| 作者单位： | 1. 浙江省杭州市药品检验所,浙江杭州,310017
2. 杭州民生药业有限公司,浙江杭州,310011 |
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| 摘 要： | 目的 建立用于测定克痢痧胶囊中丁香酚含量的气相色谱法,以提高原质量标准.方法 选用HP innowax弹性石英毛细管柱(30 mm×0.32 mm,0.25 μm);检测器为FID检测器;柱温为程序升温,初始温度为100℃,以10℃/min速率升至200 ℃,保持5 min;气体流量为1.2 mL/min(载气为氮气);分流进样,分流比为5:1,进样量为1 μL.结果 丁香酚的进样量线性范围为0.072 6~1.21μg(r=0.999 9),平均加样回收率为97.62%,RSD=0.56%(n=6).结论该测定方法简便、快速,准确性和重复性好,可用于克痢痧胶囊的质量控制.
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| 关 键 词： | 气相色谱法 克痢痧胶囊 丁香酚 |
Determination of Eugenol in Kelisha Capsules by GC |
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| Lu Zhiling,Liu Huadong. Determination of Eugenol in Kelisha Capsules by GC[J]. China Pharmaceuticals, 2012, 21(4): 32-33 |
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| Authors: | Lu Zhiling Liu Huadong |
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| Affiliation: | 1. Hangzhou Institute for Drug Control, Hangzhou, Zhejiang, China 310017; 2. Hangzhou Minsheng Pharmaceutical Group Co. , Ltd. , Hangzhou, Zhejiang , China 310011) |
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| Abstract: | Objective To develop a GC method for determining the content of eugenol in Kelisha Capsules to control the quality better. Methods The sample was analyzed by HP Innowax column（30 mm × 0.32 mm,0.25 μm）with FID detector. The initial temperature was set at 100 ℃ ,then risen to 200 ℃ with the rate of 10 ℃/min by temperature programming and kept for 5 rain. The flow rate was at 1.2 mL/min. The split ratio was 5 ： 1,the injection volume was 1 μL. Results The linear range of eugenol was 0. 072 6 - 1.21 μg （r=0.999 9）.The average recovery rate was 97.62% and RSD was 0.56% （n=6）.Conclusion The method is simple,rapid and accurate with good reproducibility, which can be used for quality control of this preparation. |
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| Keywords: | GC Kelisha Capsules eugenol |
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