外阴阴道念珠菌感染与耐药性的分析

目的观察外阴阴道各种念珠菌的感染情况,并对常用药物的耐药性进行分析。方法收集2008年6月至2011年2月700例确诊为外阴阴道念珠菌感染患者的生殖道分泌物,采用念珠菌显色平板及SIMENS MicroScan真菌(yeast)反应板进行念珠菌菌种的分离鉴定,采用ROSCOS药片法对氟康唑、咪康唑、伊曲康唑、制霉菌素、两性霉素B进行药物耐药性及敏感性试验。结果白色念珠菌占64.57%、光滑念珠菌占14.14%、克柔念珠菌占9%、其他念珠菌占12.29%。各念珠菌对两性霉素B、制霉菌素和伊曲康唑的敏感性较高,对咪康唑、氟康唑的耐药率较高。结论女性外阴阴道念珠菌以白色念珠菌居多,对抗真菌药物有不同程度的耐药,对菌种进行鉴定和药敏实验有利于临床指导用药。

The Analysis of Vulvovaginal Candida Infection and Bacterial Drug Resistance

Objective To observe the infection information of vulvovaginal candida Infection,and Analysis to Antituberculosis drug resistance.Methods Select 700 patients which make a definite diagnosis that infected vulvovaginal candida,Isolation and Identification of Candida by monilia chromogenic plate and SIMENS MicroScan fungus（yeast）reaction plate,Antifungal susceptibility of fluconazol,miconazole,Itraconazole,Nystatin,amphotericineB was assessed by Rosco Disk Diffusion method.Results Candida albicans infection accounts for 64.57%,glabrata infection accounts for 14.14%,Candida krusei infection accounts for 9%,other accounts for 12.29%.The drug sensitivity of amphotericineB,Nystatin and Itraconazole were high,and the resistance rate of Miconazole and Fluconazol were high.Conclusion Candida albicans was much more than others vulvovaginal candida,have different degree resistance,identification and antimicrobial susceptibility testing were make for direc rational administration of drug.