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| Expression of the EphA2 Gene in Esophageal Carcinoma Tissues | |
| 引用本文： | Baolan Hao Shanshan Li Hongyan Zhang Aihua Yan Xiuhua Ren Department of Pathology,Henan Tumor Hospital Zhengzhou 450008,China. Henan Key Laboratory of Tumor Pathology, Department of Pathology,The First Affiliated Hospital,Zhengzhou University,Zhengzhou 450003,China.. Expression of the EphA2 Gene in Esophageal Carcinoma Tissues[J]. 中国肿瘤临床(英文版), 2006, 3(2): 92-95. DOI: 10.1007/s11805-006-0080-6 |
| 作者姓名： | Baolan Hao Shanshan Li Hongyan Zhang Aihua Yan Xiuhua Ren Department of Pathology Henan Tumor Hospital Zhengzhou 450008 China. Henan Key Laboratory of Tumor Pathology Department of Pathology The First Affiliated Hospital Zhengzhou University Zhengzhou 450003 China. |
| 作者单位： | Baolan Hao Shanshan Li Hongyan Zhang Aihua Yan Xiuhua Ren Department of Pathology，Henan Tumor Hospital Zhengzhou 450008，China. Henan Key Laboratory of Tumor Pathology; Department of Pathology，The First Affiliated Hospital，Zhengzhou University，Zhengzhou 450003，China. |
| 摘 要： | OBJECTIVE To investigate the relationship of the EphA2 gene with the occurrence, invasion and metastasis of esophageal carcinoma. METHODS The expression of EphA2 mRNA was detected by RT-PCR and the EphA2 protein was estimated by immunohistochemistry (SP method) in both esophageal cancerous tissues and normal epithelial tissues. RESULTS The expression of EphA2 mRNA showed no difference between esophageal cancerous tissues and normal epithelium, and there appeared to be no correlation with differentiation of the cancerous tissues, the depth of infiltration or lymph node metastasis (P>0.05). However, the expression of the EphA2 protein was significantly higher in cancerous tissues compared to normal epithelial tissues (P<0.05). The expression of the EphA2 protein in a deeper invasive group and in a group with lymph node metastasis was significantly higher compared to a superficially invasive group and a group without lymph node metastasis (P<0.05). Its expression did not appear to be correlated with differentiation of cancerous tissues (P>0.05). CONCLUSION The occurrence of esophagus carcinoma and the formation of invasion and metastasis may be related to overexpression of the EphA2 protein but not to the level of mRNA, a finding which may due to up-regulation at the translation level or by increased protein stability. |
| 收稿时间： | 2006-02-22 |
| 修稿时间： | 2006-03-24 |
Expression of the EphA2 Gene in Esophageal Carcinoma Tissues |
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| Baolan Hao,Shanshan Li,Hongyan Zhang,Aihua Yan,Xiuhua Ren. Expression of the EphA2 Gene in Esophageal Carcinoma Tissues[J]. Chinese Journal of Clinical Oncology, 2006, 3(2): 92-95. DOI: 10.1007/s11805-006-0080-6 | |
| Authors: | Baolan Hao Shanshan Li Hongyan Zhang Aihua Yan Xiuhua Ren |
| Affiliation: | 1. Department of Pathology,Henan Tumor Hospital Zhengzhou 450008,China 2. Department of Pathology,The First Affiliated Hospital,Zhengzhou University,Zhengzhou 450003,China |
| Abstract: | OBJECTIVE To investigate the relationship of the EphA2 gene with the occurrence, invasion and metastasis of esophageal carcinoma. METHODS The expression of EphA2 mRNA was detected by RT-PCR and the EphA2 protein was estimated by immunohistochemistry (SP method) in both esophageal cancerous tissues and normal epithelial tissues. RESULTS The expression of EphA2 mRNA showed no difference between esophageal cancerous tissues and normal epithelium, and there appeared to be no correlation with differentiation of the cancerous tissues, the depth of infiltration or lymph node metastasis (P>0.05). However, the expression of the EphA2 protein was significantly higher in cancerous tissues compared to normal epithelial tissues (P<0.05). The expression of the EphA2 protein in a deeper invasive group and in a group with lymph node metastasis was significantly higher compared to a superficially invasive group and a group without lymph node metastasis (P<0.05). Its expression did not appear to be correlated with differentiation of cancerous tissues (P>0.05). CONCLUSION The occurrence of esophagus carcinoma and the formation of invasion and metastasis may be related to overexpression of the EphA2 protein but not to the level of mRNA, a finding which may due to up-regulation at the translation level or by increased protein stability. |
| Keywords: | esophageal neoplasm EphA2 gene RTKs metastasis. |
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