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| STAT3、VEGF基因在新疆哈萨克族食管癌中的表达及其相关性研究 | |
| 引用本文： | 王洪江,郭文佳,李卉,庞作良,陈艳,姜孝芳,张景萍,张丽萍,范志勤,赵学信,李惠武.STAT3、VEGF基因在新疆哈萨克族食管癌中的表达及其相关性研究[J].癌变．畸变．突变,2010,22(3):218-220,237. |
| 作者姓名： | 王洪江 郭文佳 李卉 庞作良 陈艳 姜孝芳 张景萍 张丽萍 范志勤 赵学信 李惠武 |
| 作者单位： | 1. 新疆医科大学附属肿瘤医院胸外科,乌鲁木齐,830011 2. 新疆医科大学基础医学院生物化学教研室,乌鲁木齐,830011 3. 新疆医科大学基础医学院科研中心,新疆地方病分子生物学实验室,乌鲁木齐830011 |
| 基金项目： | 新疆维吾尔自治区高技术研究与发展计划项目 |
| 摘 要： | |
| 关 键 词： | 哈萨克族食管癌 转导和转录激活因子3 血管内皮细胞生长因子 逆转录聚合酶链式反应 |
Expression of STAT3,VEGF in esophageal carcinoma and its correlation in Xinjiang Kazaks |
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| WANG Hong-jiang,GUO Wen-jia,LI Hui,PANG Zuo-liang,CHEN Yan,JIANG Xiao-fang,ZHANG Jing-ping,ZHANG Li-ping,FAN Zhi-qin,ZHAO Xue-xin,LI Hui-wu.Expression of STAT3,VEGF in esophageal carcinoma and its correlation in Xinjiang Kazaks[J].Carcinogenesis,Teratogenesis and Mutagenesis,2010,22(3):218-220,237. | |
| Authors: | WANG Hong-jiang GUO Wen-jia LI Hui PANG Zuo-liang CHEN Yan JIANG Xiao-fang ZHANG Jing-ping ZHANG Li-ping FAN Zhi-qin ZHAO Xue-xin LI Hui-wu |
| Institution: | WANG Hong-jiang1,GUO Wen-jia2,#,LI Hui3,PANG Zuo-liang1,CHEN Yan2,JIANG Xiao-fang3,ZHANG Jing-ping2,ZHANG Li-ping2,FAN Zhi-qin1,ZHAO Xue-xin2,LI Hui-wu3(1.Department of Thoracic Surgery,Affiliated Cancer Hospital;2.Department of Biochemistry,Pre-clinical Medicine College;3.Department of Science Research Center,Pre-clinical Medicine College,Xinjiang Medical University,Urumqi 830011,China) |
| Abstract: | OBJECTIVE:To study the expressions of STAT3 and VEGF gene and to explore their roles in the process of esophageal cancer in the Kazaks.METHODS:Using RT-PCR to detect STAT3,VEGF in 30 cases of esophageal cancer tissues and their corresponding adjacent tissues.RESULTS:The positive rate of STAT3,VEGF mRNA expressions were 73.33%(22/30)and 76.67%(23/30),respectively,in the esophageal cancers,and 43.33%(13/30)in adjacent tissues.There was significant difference in the expressions of STAT3,VEGF mRNA level between tumor tissue and adjacent tissues.CONCLUSION:STAT3,VEGF gene could have important roles in carcinogenesis of esophageal cancer in the Kazaks.The combined action of STAT3 and VEGF genes could promote carcinogenesis and development of esophageal cancer. |
| Keywords: | esophageal cancer in the Kazaks STAT3 VEGF RT-PCR |
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