肝素治疗小儿重症肺炎的疗效及对血小板参数和D-二聚体的影响

目的探讨肝素治疗小儿重症肺炎的疗效及对血小板数参数和D-二聚体(D-Dimer)的影响。方法将95例小儿肺炎患儿随机分为治疗组48例和对照组47例。两组患儿均给予常规治疗,治疗组在此基础上加用小剂量肝素治疗。于治疗前及治疗后检测两组血小板参数及D-Dimer浓度。结果治疗组的总有效率为95.8%,显著高于对照的76.6%(P<0.01)。经治疗后,治疗组的血小板参数测定值较治疗前明显改善(P<0.01),且与对照组比较有极显著性差异(P<0.01);治疗组D-Dimer升高者仅占6.3%,显著低于对照组的51.1%(P<0.01)。结论肝素治疗小儿重症肺炎疗效显著,能明显改善患儿的高凝状态。

Curative Effect of Heparin in the Treatment of Children with Severe Pneumonia and Its Influence on Platelet Parameters and D-Dimer

Objective To observe the therapeutic effects of heparin in the treatment of children with severe pneumonia and its influence on platelet parameters and D-Dimer.Methods Ninety-five children with severe pneumonia were divided randomly into treatment group(n=48)and control group(n=47),two groups received conventional treatment,moreover,the treatment group was treated with subcutaneously small dosage of heparin.Serum platelet parameters and D-Dimer were measured before and after treatment.Results The total effectiveness rate of the treatment group was significantly higher than that of control group(95.8% vs 76.6%,P<0.01).Comparison with those before treatment,the platelet parameters in the treatment group improved obviously after treatment(P<0.01),and there was significant difference as compared with control group(P<0.01).The rate of increased D-Dimer in therapy group was significantly lower than that of control group after treatment(6.3% vs 51.1%,P<0.01).Conclusion Heparin is an effective drug for the treatment of children with severe pneumonia,which can obviously improve blood hypercoagulable state.