抗焦虑治疗对老年高血压病患者血管内皮功能的影响

目的 研究抗焦虑治疗对老年高血压病患者降压疗效以及血管内皮功能的影响。方法高血压病患者予以汉密顿焦虑量表(HAMA)测定，量表测定为阳性的病例分为A、B两组，阴性患者作为C组，均口服氮氯地平，A组病例同时加服黛力新片。疗程均为6个月。测定治疗前、后24h平均血压、汉密顿焦虑量表、一氧化氮(NO)、内皮素(ET)、血栓素(TXB2)、前列环素(PGI2)。结果 A、B、C三组降压有效率分别为89．47％、67．65％、82．86％；经降压治疗后各组ET、TXB2均显著下降，而A组ET、TXB2的下降较B组更为明显，有显著性差异；且A组治疗前后血浆NO水平有明显升高，与B、C二组相比有显著性差异。结论 伴有焦虑情绪的老年高血压患者加用抗焦虑治疗既能改善患者的焦虑情绪，又能增加降压药物的疗效，同时能减轻血管内皮功能的损伤。

Effects of anti-anxiety therapy on decrease of blood pressure and change of endothelial function in elderly patients with hypertension

ObjectiveTo study the effects of decrease of blood pressure and endothelial function by anti-anxiety in old patients with hypertension. MethodsHypertensive patients were divided into three groups. The group A and B were those who got positive result during HAMA scale rating and those who got normal scores belong to group C. All the patients were treated with oral dose of Amlodipine for six months, while the group A patients took Deanxit once every day. ResultsThe effective rates of decrease blood pressure in three groups were 89.47 %,67.65%,82.86% respectively. All the patients had significant improvement in the plasma levels of ET and TXB 2 , especially more significant between group A and B. Compared with group B and C, there was a significant higher NO level after treatment in group A. ConclusionAnti-anxiety therapy may improve anxiety and increase curative effect of antihypertensive drug, as well as, improve the injury of vascular endothelial function in elderly hypertensive patients with anxiety.