羟基喜树碱与噻替哌灌注化疗对膀胱肿瘤术后临床预后的meta分析

目的：评价膀胱肿瘤术后灌注羟基喜树碱（HCPT）和噻替哌（TT）对预防肿瘤复发的效果及其不良反应。方法：计算机检索Pubmed、Cochrane Library、CNKI、CBM、VIP及万方数据库,收集关于HCPT与TT膀胱灌注治疗肿瘤复发的随机对照实验（RCT）,两名研究者根据纳入排除标准独立筛选文献,应用Revman5．0和Stata11．0进行数据处理。结果：通过筛选共纳入4个RCTs。meta分析结果提示,羟基喜树碱膀胱肿瘤术后灌注较噻替哌更能有效降低肿瘤复发风险（P=0．01）。2个研究报道了药物引起的不良反应,分析结果显示两者差异无统计学意义（P〉0．05）。结论：膀胱肿瘤术后灌注羟基喜树碱较噻替哌更能有效降低肿瘤复发率,虽然有一定的不良反应,但都较轻微。

Meta-analysis of hydroxy camptothecin versus thiotepa for intravesical perfusion after surgical procedure of bladder tumor

Objective： To evaluate the efficiency and side effects caused by intravesical perfusion of hydroxy camptothecin （HCPT） and thiotepa （TT） in preventing the recurrence of bladder cancer postoperatively. Method.. Randomized controlled trials （RCTs） about intravesical perfusion of HCPT and TT for bladder tumor were re-trieved on computer in Pubmed, Cochrane Library, CNKI, CBM, VIP and WanFang database. According to the inclusion and exclusion criteria, two researchers independently screened the trials, extracted the data, assessed the quality, finally conducted meta-analysis with Revman 5.0 and Stata 11, 0 software. Result： A total of four RCTs were eligible. The results of meta-analysis showed that HCPT could more efficiently reduce the risk of recurrence of bladder tumor than TT （P=0.01）. Two studies of the side effects caused by this treatments showed that there was no statistically difference （P〉0.05）. Conclusion： Intravesical perfusion of HCPT after surgical procedure can more effectively reduce the rate of recurrence of bladder tumor than TT and reveal less side effects.